Details for Patent: 8,410,131
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Title: | Cancer treatment |
Abstract: | Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent. |
Inventor(s): | Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH) |
Assignee: | Novartis Pharmaceuticals Corporation (East Hanover, NJ) |
Filing Date: | Feb 18, 2002 |
Application Number: | 10/468,520 |
Claims: | 1. A method for inhibiting growth of solid excretory system tumors in a subject, said method consisting of administering to said subject a therapeutically effective amount of a compound of formula I ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O. 2. The method of claim 1 wherein the solid excretory system tumor is an advanced solid excretory system tumor. 3. The method of claim 1 wherein the solid excretory system tumor is a kidney tumor. 4. The method of claim 1 wherein the solid excretory system tumor is a tumor of the renal pelvis. 5. The method of claim 1 wherein the compound of formula I is administered orally. 6. The method of claim 5 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses. 7. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg. 8. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg. 9. The method of claim 8 wherein the compound of formula I is administered in a unit dosage form of 10 mg. |