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Details for Patent: 8,372,981

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Details for Patent: 8,372,981

Title:Nitrogen-containing aromatic derivatives
Abstract: Compounds represented by the following general formula: ##STR00001## wherein A.sup.g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X.sup.g is --O--, --S--, etc.; Y.sup.g is an optionally substituted C.sub.6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T.sup.g1 is a group represented by the following general formula: ##STR00002## (wherein E.sup.g is a single bond or --N(R.sup.g2)--), R.sup.g1 and R.sup.g2 each independently represent a hydrogen atom, an optionally substituted C.sub.1-6 alkyl group, etc. and Z.sup.g represents a C.sub.1-8 alkyl group, a C.sub.3-8 alicyclic hydrocarbon group, a C.sub.6-14 aryl group, etc.), salts thereof or hydrates of the foregoing.
Inventor(s): Funahashi; Yasuhiro (Nagoya, JP), Matsukura; Masayuki (Tsukuba, JP), Watanabe; Tatsuo (Inzai, JP), Obaishi; Hiroshi (Tsukuba, JP), Matsui; Junji (Toride, JP)
Assignee: Eisai R&D Management Co., Ltd. (Tokyo, JP)
Filing Date:Jan 07, 2011
Application Number:12/986,638
Claims:1. The compound represented by the following general formula or a salt thereof: ##STR01211## wherein W.sup.41 and W are each independently an optionally substituted carbon atom; X.sup.y1 is an optionally substituted group selected from the group consisting of the following formulas: ##STR01212## wherein Z.sup.12 is a hydrogen atom, an optionally substituted C.sub.1-6 alkyl group, an optionally substituted C.sub.2-6 alkenyl group, an optionally substituted C.sub.2-6 alkynyl group, an optionally substituted C.sub.3-8 alicyclic hydrocarbon group, an optionally substituted C.sub.6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, an optionally substituted 5- to 14-membered aromatic heterocyclic group or a group represented by the formula: ##STR01213## wherein Z.sup.31, Z.sup.33 and Z.sup.34 are each independently a methylene group, --CO--, --NH-- or --O--, and Z.sup.32 is a single bond, a methylene group, --CO--, --NH-- or --O--; and A.sup.b11 is (1) an optionally substituted 5- to 14-membered heterocyclic group or (2) a group represented by the formula: ##STR01214## wherein V.sup.b11 and V.sup.b12 are each independently a single bond, --SO.sub.2--, --NHCO-- or a group represented by the formula --(CH.sub.2).sub.b--CO-- wherein b is an integer of 0 to 6; R.sup.b13 is a single bond, an optionally substituted C.sub.1-6 alkylene group, an optionally substituted C.sub.3-8 alicyclic hydrocarbon group or an optionally substituted 5- to 14-membered heterocyclic group; and R.sup.b11 and R.sup.b12 are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an optionally substituted C.sub.1-6 alkyl group, an optionally substituted C.sub.2-6 alkenyl group, an optionally substituted C.sub.2-6 alkynyl group, an optionally substituted C.sub.3-8 alicyclic hydrocarbon group, an optionally substituted C.sub.6-14 aryl group, an optionally substituted 5- to 14-membered aromatic heterocyclic group or an optionally substituted 5- to 14-membered heterocyclic group.

2. The compound or a salt thereof according to claim 1, wherein the compound is selected from the group consisting of N-[4-(2-butylaminopyridin-4-yl)oxyphenyl]-N'-(4-fluorophenyl)urea, ethyl (E)-3-[2-[(cyclopropylcarbonyl)amino]-4-(4-{[(4-fluoroanilino)carbonyl]am- ino}phenoxy)-3-pyridyl]-2-propenoate, N1-Cyclopropylcarbonyl-N-1-[3-(1-ethynyl)-4-(4-{[(4-fluoroanilino)carbony- l]amino}phenoxy)-2-pyridyl]-1-cyclopropanecarboxamide, N4-(4-{4-[(anilinocarbonyl)amino]-3-chlorophenoxy}-2-pyridyl)-1-methyl-4-- piperidinecarboxamide, N4-[4-(3-chloro-4-[(cyclopropylamino)carbonyl]amino}phenoxy)-2-pyridyl]-1- -methyl-4-piperidinecarboxamide, N4-[4-(3-chloro-4-{[(4-fluoroanilino)carbonyl]amino}phenoxy)-2-pyridyl]-4- -piperidinecarboxamide, N4-[4-(3-chloro-4-{[(4-fluoroanilino)carbonyl]amino}phenoxy)-2-pyridyl]-1- -methyl-4-piperidinecarboxamide, N1-(4-{4-[(anilinocarbonyl)amino]-3-chlorophenoxy}-2-pyridyl)-2-(1-methyl- -4-piperidyl)acetamide, N-[4-(2-cyclobutanecarbonylaminopyridin-4-yl)oxyphenyl]-N'-(2-thiazolyl)u- rea, N1-[4-{[(cyclopropylamino)carbonyl]amino}-3-chlorophenoxy]-2-pyridyl]- -1-cyclopropanecarboxamide, N1-[5-bromo-4-(4-{[(cyclopropylamino)carbonyl]amino}-3-chlorophenoxy)-2-p- yridyl]-1-cyclopropanecarboxamide, N1-[4-(3,5-dichloro-4-{[(cyclopropylamino)carbonyl]amino}phenoxy)-2-pyrid- yl]-1-cyclopropanecarboxamide, N-[4-(2-cyclobutanecarbonylaminopyridin-4-yl)oxyphenyl]-N'-(4-fluoropheny- l)urea, N-[4-(2-butanoylaminopyridin-4-yl)oxyphenyl]-N'-(4-fluorophenyl)ur- ea, N-{4-[2-(4-ethoxycarbonylbutanoyl)aminopyridin-4-yl]oxyphenyl}-N'-(4-f- luorophenyl)urea, N-[4-(2-nicotinoylaminopyridin-4-yl)oxyphenyl]-N'-(4-fluorophenyl)urea, N-{4-[2-(4-carboxybutanoyl)aminopyridin-4-yl]oxyphenyl}-N'-(4-fluoropheny- l)urea, N-(4-{2-[(cyclopropylmethyl)aminocarbonyl]pyridin-4-yl}oxyphenyl)-- N'-(4-fluorophenyl)urea and N-{4-[2-(butyroylamino)pyridin-4-yl]oxyphenyl}-N'-cyclopropylurea.
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