Details for Patent: 8,367,657

Title:	Processes for preparing 3-benzazepines
Abstract:	The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
Inventor(s):	Wolgast; Beverly L. (San Diego, CA), Gilson, III; Charles A. (San Diego, CA), Aytes; Shelley (San Diego, CA), Estrada; Scott A. (La Jolla, CA), Sengupta; Dipanjan (San Diego, CA), Smith; Brian (San Diego, CA), Rey; Max (Wallisellen, CH), Weigl; Ulrich (Hilzingen, DE)
Assignee:	Arena Pharmaceuticals, Inc. (San Diego, CA)
Filing Date:	Jun 16, 2004
Application Number:	10/560,953
Claims:	1. A hydrochloric acid salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 2. The hydrochloric acid salt of claim 1, wherein said hydrochloric acid salt is a hydrate. 3. A L-(+)-tartaric acid salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 4. A composition comprising a hydrochloric acid salt according to claim 1. 5. A method for treating obesity comprising administering to a patient in need of such treatment a hydrochloric acid salt according to claim 1. 6. A method for decreasing food intake in a patient comprising administering to a patient in need thereof a hydrochloric acid salt according to claim 1. 7. A method for inducing satiety in a patient comprising administering to a patient in need thereof a hydrochloric acid salt according to claim 1. 8. A method for controlling weight gain in a patient comprising administering to a patient in need thereof a hydrochloric acid salt according to claim 1. 9. A method for the management of obesity in a patient comprising administering to a patient in need thereof a hydrochloric acid salt according to claim 1. 10. The method according to claim 9, wherein said method for the management of obesity comprises a method for decreasing body weight. 11. The method according to claim 9, wherein said method for the management of obesity comprises a method for maintaining body weight. 12. The method according to claim 9, wherein said patient has an initial body mass index of greater than 30 kg/m.sup.2.