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Last Updated: April 26, 2024

Details for Patent: 8,216,560


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Title:Ion binding polymers and uses thereof
Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
Inventor(s): Charmot; Dominique (Campbell, CA), Chang; Han Ting (Livermore, CA), Fordtran; John (Dallas, TX), Klaerner; Gerrit (San Jose, CA), Buysse; Jerry M. (Los Altos, CA), Alpern; Robert (Dallas, TX), Liu; Mingjun (Campbell, CA)
Assignee: Relypsa, Inc. (Santa Clara, CA)
Filing Date:Mar 26, 2008
Application Number:12/055,726
Claims:1. A method for removing potassium from a patient in need thereof comprising administering a potassium-binding polymer in an oral dosage form to a patient having renal insufficiency, the patient being treated for the renal insufficiency with a potassium-sparing diuretic, an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, a non-steroidal anti-inflammatory drug, heparin, or trimethoprim and the potassium-binding polymer comprising a crosslinked cation exchange polymer in a bead form, the crosslinked cation exchange polymer comprising a carboxylic acid group having a fluoride attached to the carbon atom alpha to the carboxylic acid group.

2. The method of claim 1 wherein the patient is being treated with an angiotensin-converting enzyme inhibitor.

3. The method of claim 1 wherein the patient is being treated with an angiotensin receptor blocker.

4. The method of claim 1 wherein the patient suffers from hyperkalemia.

5. The method of claim 1 wherein the potassium-binding polymer and the potassium-sparing diuretic, the angiotensin-converting enzyme inhibitor, the angiotensin receptor blocker, the non-steroidal anti-inflammatory drug, heparin, or trimethoprim are administered simultaneously.

6. A method for removing potassium from a patient in need thereof comprising administering a therapeutically effective amount of a potassium-binding polymer in an oral dosage form to a patient having renal insufficiency, the patient being treated for the renal insufficiency with a potassium-sparing diuretic, an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, a non-steroidal anti-inflammatory drug, heparin, or trimethoprim and the potassium-binding polymer being a crosslinked alpha-fluoroacrylic acid polymer comprising a Ca.sup.2+ cationic counterion.

7. The method of claim 6 wherein the crosslinked alpha-fluoroacrylic acid polymer has a swelling ratio of less than about 3.

8. The method of claim 6 wherein the alpha-fluoroacrylic acid polymer is crosslinked with divinylbenzene, ethylene bisacrylamide, N,N'- bis(vinylsulfonylacetyl) ethylene diamine, 1,3-bis(vinylsulfonyl) 2-propanol, vinylsulfone, N,N'-methylenebisacrylamide polyvinyl ether, polyallylether, or a combination thereof.

9. The method of claim 6 wherein the potassium-binding polymer is in a bead form.

10. The method of claim 6 wherein the patient is being treated with an angiotensin-converting enzyme inhibitor.

11. The method of claim 6 wherein the patient is being treated with an angiotensin receptor blocker.

12. A method for removing potassium from a patient in need thereof, the patient suffering from congestive heart failure (CHF), the method comprising administering a potassium-binding polymer in an oral dosage form to the patient, the potassium-binding polymer comprising a crosslinked cation exchange polymer in a bead form, the crosslinked cation exchange polymer comprising a carboxylic acid group having a fluoride attached to the carbon atom alpha to the carboxylic acid group.

13. The method of claim 12 wherein the patient is also being treated with a potassium-sparing diuretic.

14. The method of claim 12 wherein the patient is also being treated with an angiotensin-converting enzyme inhibitor.

15. The method of claim 13 wherein the potassium-binding polymer and the potassium-sparing diuretic are administered simultaneously.

16. The method of claim 14 wherein the potassium-binding polymer and the angiotensin-converting enzyme inhibitor are administered simultaneously.

17. A method for removing potassium from a patient in need thereof, the patient suffering from congestive heart failure (CHF), the method comprising administering a potassium-binding polymer in an oral dosage form to the patient, the potassium-binding polymer being a crosslinked alpha-fluoroacrylic acid polymer comprising a Ca.sup.2+ cationic counterion.

18. The method of claim 17 wherein the crosslinked alpha-fluoroacrylic acid polymer has a swelling ratio of less than about 3.

19. The method of claim 17 wherein the alpha-fluoroacrylic acid polymer is crosslinked with divinylbenzene, ethylene bisacrylamide, N,N'- bis(vinylsulfonylacetyl) ethylene diamine, 1,3-bis(vinylsulfonyl) 2-propanol, vinylsulfone, N,N'-methylenebisacrylamide polyvinyl ether, polyallylether, or a combination thereof.

20. The method of claim 17 wherein the potassium-binding polymer is in a bead form.

21. The method of claim 17 wherein the patient is also being treated with a potassium-sparing diuretic.

22. The method of claim 17 wherein the patient is also being treated with an angiotensin-converting enzyme inhibitor.

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