Details for Patent: 8,101,593
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Title: | Formulations of deoxycholic acid and salts thereof |
Abstract: | The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5. |
Inventor(s): | Hodge; Robert Emil (Thousand Oaks, CA), Webster; Jeffrey Douglas (Thousand Oaks, CA) |
Assignee: | Kythera Biopharmaceuticals, Inc. (Calabasas, CA) |
Filing Date: | Mar 02, 2010 |
Application Number: | 12/716,070 |
Claims: | 1. An aqueous pharmaceutical formulation consisting of from about 0.5% w/v to about 1.5% w/v deoxycholate and at least one pharmaceutically acceptable excipient and/or carrier wherein the formulation has a pH of from about 8.0 to about 8.5. 2. The aqueous pharmaceutical formulation of claim 1, wherein the aqueous formulation is suitable for subcutaneous injection. 3. The aqueous pharmaceutical formulation of claim 1 or claim 2, wherein said at least one pharmaceutically acceptable excipient and/or carrier is selected from the group consisting of water, a buffer, and a preservative. |