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Generated: September 21, 2017

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Title:Hydrochloride salts of a glycopeptide phosphonate derivative
Abstract: Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
Inventor(s): Liu; Jyanwei (Sunnyvale, CA), Lee; Junning (El Granada, CA)
Assignee: Thervance, Inc. (South San Francisco, CA)
Filing Date:Apr 08, 2008
Application Number:12/082,096
Claims:1. A process for preparing a hydrochloride salt of telavancin; the process comprising: (a) forming an aqueous composition comprising a hydrochloride salt of telavancin, wherein the aqueous composition has a pH of about 3.5 to about 4.5; (b) adding an organic diluent to the aqueous composition of step (a) to precipitate the hydrochloride salt of telavancin; and (c) filtering the aqueous composition of step (b) to provide the hydrochloride salt of telavancin.

2. The process of claim 1, wherein the aqueous composition has a pH of about 3.5 to about 4.0.

3. The process of claim 1 or 2, wherein the organic diluent is acetonitrile.

4. The process of claim 1 or 2, wherein the organic diluent is acetone.

5. The process of claim 1 or 2, wherein the process further comprises: (d) washing the hydrochloride salt of telavancin from step (c) with methyl tert-butyl ether.
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