|Title:||Hydrochloride salts of a glycopeptide phosphonate derivative|
|Abstract:||Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.|
|Inventor(s):||Liu; Jyanwei (Sunnyvale, CA), Lee; Junning (El Granada, CA)|
|Assignee:||Thervance, Inc. (South San Francisco, CA)|
|Filing Date:||Apr 08, 2008|
|Claims:||1. A process for preparing a hydrochloride salt of telavancin; the process comprising: (a) forming an aqueous composition comprising a hydrochloride salt of telavancin, wherein the aqueous composition has a pH of about 3.5 to about 4.5; (b) adding an organic diluent to the aqueous composition of step (a) to precipitate the hydrochloride salt of telavancin; and (c) filtering the aqueous composition of step (b) to provide the hydrochloride salt of telavancin. |
2. The process of claim 1, wherein the aqueous composition has a pH of about 3.5 to about 4.0.
3. The process of claim 1 or 2, wherein the organic diluent is acetonitrile.
4. The process of claim 1 or 2, wherein the organic diluent is acetone.
5. The process of claim 1 or 2, wherein the process further comprises: (d) washing the hydrochloride salt of telavancin from step (c) with methyl tert-butyl ether.
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