Details for Patent: 7,956,052
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Title: | Modulators of ATP-binding cassette transporters |
Abstract: | Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. |
Inventor(s): | Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Oceanside, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA), van Goor; Fredrick (San Diego, CA) |
Assignee: | Vertex Pharmaceuticals Incorporated (Cambridge, MA) |
Filing Date: | Dec 04, 2009 |
Application Number: | 12/630,874 |
Claims: | 1. A method of treating or lessening the severity of cystic fibrosis in a patient, comprising the step of administering to said patient an effective amount of a compound selected from the following TABLE-US-00008 423 ##STR00700## 424 ##STR00701## 425 ##STR00702## 426 ##STR00703## 427 ##STR00704## 428 ##STR00705## 429 ##STR00706## 430 ##STR00707## 431 ##STR00708## 432 ##STR00709## 433 ##STR00710## 434 ##STR00711## 435 ##STR00712## 436 ##STR00713## 437 ##STR00714## 438 ##STR00715## 439 ##STR00716## 440 ##STR00717## 441 ##STR00718## 442 ##STR00719## 443 ##STR00720## 444 ##STR00721## 445 ##STR00722## 446 ##STR00723## 447 ##STR00724## 448 ##STR00725## 449 ##STR00726## 450 ##STR00727## 451 ##STR00728## 452 ##STR00729## 453 ##STR00730## 454 ##STR00731## 455 ##STR00732## 456 ##STR00733## 457 ##STR00734## 458 ##STR00735## 459 ##STR00736## 460 ##STR00737## 461 ##STR00738## 462 ##STR00739## 463 ##STR00740## 465 ##STR00741## 466 ##STR00742## 467 ##STR00743## 468 ##STR00744## 469 ##STR00745## 470 ##STR00746## 471 ##STR00747## 472 ##STR00748## 473 ##STR00749## 474 ##STR00750## 475 ##STR00751## 476 ##STR00752## 477 ##STR00753## 478 ##STR00754## 479 ##STR00755## 480 ##STR00756## 481 ##STR00757## 482 ##STR00758## 483 ##STR00759## 484 ##STR00760## 485 ##STR00761## 486 ##STR00762## 487 ##STR00763## 488 ##STR00764## 489 ##STR00765## 490 ##STR00766## 491 ##STR00767## 492 ##STR00768## 493 ##STR00769## 494 ##STR00770## 495 ##STR00771## 496 ##STR00772## 497 ##STR00773## 498 ##STR00774## 499 ##STR00775## 500 ##STR00776## 501 ##STR00777## 502 ##STR00778## 503 ##STR00779## 504 ##STR00780## 505 ##STR00781## 506 ##STR00782## 507 ##STR00783## 508 ##STR00784## 509 ##STR00785## 510 ##STR00786## 511 ##STR00787## 512 ##STR00788## 513 ##STR00789## 514 ##STR00790## 515 ##STR00791## 516 ##STR00792## 517 ##STR00793## 518 ##STR00794## 519 ##STR00795## 520 ##STR00796## 521 ##STR00797## 522 ##STR00798## 523 ##STR00799## 524 ##STR00800## 525 ##STR00801## 526 ##STR00802## 527 ##STR00803## or 528 ##STR00804## |