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Generated: August 17, 2017

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Title:1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. ##STR00001## In the formula, Q indicates NH, O or S; and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group or a group represented by the formula --X-A (wherein X indicates a single bond, an optionally substituted C.sub.1-6 alkylene group etc.; and A indicates an optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
Inventor(s): Nagato; Satoshi (Chiba, JP), Ueno; Kohshi (Ibaraki, JP), Kawano; Koki (Ibaraki, JP), Norimine; Yoshihiko (Ibaraki, JP), Ito; Koichi (Chiba, JP)
Assignee: Eisai R&D Management Co., Ltd. (Tokyo, JP)
Filing Date:Feb 27, 2009
Application Number:12/395,378
Claims:1. A compound represented by the following formula, a salt thereof or a hydrate thereof ##STR01319## wherein A.sup.1a and A.sup.3a are the same as or different from each other and each indicates optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group or 5 to 14-membered aromatic heterocyclic group; and R indicates hydrogen atom or a halogen atom.

2. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a and A.sup.3a are the same as or different from each other and each represents optionally substituted phenyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, thienyl group, thiazolyl group, furyl group, naphthyl group, quinolyl group, isoquinolyl group, indolyl group, benzimidazolyl group, benzothiazolyl group, benzoxazolyl group, imidazopyridyl group or carbazolyl group.

3. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a and A.sup.3a are the same as or different from each other and each represents optionally substituted phenyl group, pyridyl group, pyrimidinyl group, thienyl group or furyl group.

4. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein R is a hydrogen atom or bromine.

5. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a is an optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group, A.sup.3a is an optionally substituted 5 to 14-membered aromatic heterocyclic group, and R is a halogen atom.

6. The compound according to claim 5, a salt thereof or a hydrate thereof, wherein the compound is 3-bromo-1-phenyl-5-pyridin-2-yl-2(1H)-pyridone.
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