.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,939,549

« Back to Dashboard

Details for Patent: 7,939,549

Title:1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. ##STR00001## In the formula, Q indicates NH, O or S; and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group or a group represented by the formula --X-A (wherein X indicates a single bond, an optionally substituted C.sub.1-6 alkylene group etc.; and A indicates an optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
Inventor(s): Nagato; Satoshi (Chiba, JP), Ueno; Kohshi (Ibaraki, JP), Kawano; Koki (Ibaraki, JP), Norimine; Yoshihiko (Ibaraki, JP), Ito; Koichi (Chiba, JP)
Assignee: Eisai R&D Management Co., Ltd. (Tokyo, JP)
Filing Date:Feb 27, 2009
Application Number:12/395,378
Claims:1. A compound represented by the following formula, a salt thereof or a hydrate thereof ##STR01319## wherein A.sup.1a and A.sup.3a are the same as or different from each other and each indicates optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group or 5 to 14-membered aromatic heterocyclic group; and R indicates hydrogen atom or a halogen atom.

2. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a and A.sup.3a are the same as or different from each other and each represents optionally substituted phenyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, thienyl group, thiazolyl group, furyl group, naphthyl group, quinolyl group, isoquinolyl group, indolyl group, benzimidazolyl group, benzothiazolyl group, benzoxazolyl group, imidazopyridyl group or carbazolyl group.

3. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a and A.sup.3a are the same as or different from each other and each represents optionally substituted phenyl group, pyridyl group, pyrimidinyl group, thienyl group or furyl group.

4. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein R is a hydrogen atom or bromine.

5. The compound according to claim 1, a salt thereof or a hydrate thereof, wherein A.sup.1a is an optionally substituted C.sub.6-14 aromatic hydrocarbocyclic group, A.sup.3a is an optionally substituted 5 to 14-membered aromatic heterocyclic group, and R is a halogen atom.

6. The compound according to claim 5, a salt thereof or a hydrate thereof, wherein the compound is 3-bromo-1-phenyl-5-pyridin-2-yl-2(1H)-pyridone.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc