Details for Patent: 7,919,625
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Title: | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) |
Abstract: | Compounds of the formula: ##STR00001## wherein: n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R.sup.1 is 2,4-diCl, 5-OMe; 2,4-diCl; 3,4,5-tri-OMe; 2-Cl, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCl, 5-OEt; R.sup.2 is alkyl of 1 to 2 carbon atoms, and pharmaceutically acceptable salts thereof. |
Inventor(s): | Boschelli; Frank (New City, NY), Golas; Jennifer M. (West Milford, NJ), Arndt; Kim T. (Towaco, NJ) |
Assignee: | Wyeth LLC (Madison, NJ) |
Filing Date: | Jun 16, 2008 |
Application Number: | 12/139,834 |
Claims: | 1. A pharmaceutical composition comprising a CML inhibiting amount of the compound 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl- -1-piperazinyl)propoxy]-3-quinolinecarbonitrile. |