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|Title:||Glucagon-like peptide-2 and its therapeutic use|
|Abstract:||Glucagon-like peptide 2, a product of glucagon gene expression, and analogs of glucagon-like peptide 2, have been identified as gastrointestinal tissue growth factors. Their effects on the growth of small bowel and pancreatic islets are described. Their formulation as a pharmaceutical, and their therapeutic use in treating disorders of the bowel, are described.|
|Inventor(s):||Drucker; Daniel J. (Toronto, CA)|
|Assignee:||NPS Pharmaceuticals, Inc. (Bedminster, NJ)|
|Filing Date:||Jan 05, 2006|
|Claims:||1. A method for promoting an increase of the crypt plus villus height in a patient in need thereof, comprising the step of delivering to the patient a pharmaceutical composition comprising a mammalian GLP-2 and a pharmaceutically acceptable carrier. |
2. The method for promoting an increase of the crypt plus villus height in a patient in need thereof according to claim 1, wherein the peptide is a mammalian GLP-2.
3. The method for promoting an increase of the crypt plus villus height in a patient in need thereof according to claim 1, wherein the mammalian GLP-2 is human GLP-2 (SEQ ID NO: 4).
4. The method for promoting an increase of the crypt plus villus height in a patient in need thereof according to claim 1, wherein the mammalian GLP-2 is rat GLP-2 (SEQ ID NO: 3).
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