.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,858,788

« Back to Dashboard

Details for Patent: 7,858,788

Title:Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
Abstract: Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and an agent, particularly an anti-HIV agent. A compound represented by the formula: ##STR00001## (wherein Z.sup.1 is NR.sup.4 (R.sup.4 is hydrogen, optionally substituted lower alkyl etc.), O or CH.sub.2; Z.sup.2 is optionally substituted lower alkylene or optionally substituted lower alkenylene, each may be intervened by a heteroatom group selected from group consisting O, S, SO, SO.sub.2, NR.sup.5 (R.sup.5 is selected independently from the same substituent group of R.sup.4) --N.dbd. and .dbd.N--; R.sup.1 is hydrogen or lower alkyl; X is a single bond, a heteroatom group selected from O, S, SO, SO.sub.2 and NH, or lower alkylene or lower alkenylene each may be intervened by the heteroatom group; R.sup.2 is optionally substituted aryl; R.sup.3 is hydrogen, halogen, hydroxy, optionally substituted alkyl group etc.)
Inventor(s): Yoshida; Hiroshi (Osaka, JP), Kawasuji; Takashi (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP)
Assignee: Shionogi & Co., Ltd. (Osaka, JP)
Filing Date:Feb 20, 2006
Application Number:11/884,686
Claims:1. A compound represented by the formula: ##STR00042## (wherein, R.sup.1 is hydrogen or lower alkyl; X is a single bond, a heteroatom group selected from 0, S, SO, SO.sub.2 and NH, or lower alkylene or lower alkenylene each may be intervened by the heteroatom group; R.sup.2 is optionally substituted aryl; R.sup.3 is hydrogen, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterocyclic group, optionally substituted heterocycleoxy or optionally substituted amino; R.sup.4 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkyl lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted aryl, optionally substituted aryl lower alkyl, optionally substituted aryloxy, optionally substituted heterocycle, optionally substituted heterocycle lower alkyl, optionally substituted heterocycleoxy, hydroxy, optionally substituted amino, optionally substituted phosphoric acid residue, aryl substituted with optionally substituted phosphoric acid residue, aralkyl substituted with optionally substituted phosphoric acid residue, hydroxy substituted with optionally substituted phosphoric acid residue, amino substituted with optionally substituted phosphoric acid residue or lower alkyl substituted with optionally substituted phosphoric acid residue (the lower alkyl may be intervened by a heteroatom group selected from group consisting O, S, SO, SO.sub.2, NR.sup.a (R.sup.a is hydrogen or lower alkyl), --N.dbd. and .dbd.N--)), or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen; X is lower alkylene; R.sup.2 is phenyl, or phenyl substituted with at least halogen; and R.sup.3 is hydrogen, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy or optionally substituted amino.

3. A pharmaceutical composition, containing a compound as defined in claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc