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Details for Patent: 7,713,995

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Details for Patent: 7,713,995

Title:Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Abstract: Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
Inventor(s): Weiner; David M. (San Diego, CA), Davis; Robert E. (San Diego, CA), Brann; Mark R. (Rye, NH), Nash; Norman (San Diego, CA), Andersson; Carl-Magnus A. (Hjarup, SE), Uldam; Allan K. (Ballerup, DK)
Assignee: Acadia Pharmaceuticals, Inc. (San Diego, CA)
Filing Date:May 03, 2006
Application Number:11/416,594
Claims:1. A method of treating a sleep disorder, comprising administering to a subject having a sleep disorder a therapeutically effective amount of the compound of formula (I): ##STR00010## or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein the sleep disorder is associated with dysfunction of a monoamine receptor.

3. The method of claim 1, wherein the sleep disorder is associated with activation of a monoamine receptor.

4. The method of claim 1, wherein the sleep disorder is associated with increased activity of a monoamine receptor.

5. The method of claim 2, wherein the monoamine receptor is a serotonin receptor.

6. The method of claim 5, wherein the serotonin receptor is the 5-HT2A subclass.

7. The method of claim 5, wherein the serotonin receptor is in central nervous system.

8. The method of claim 1, wherein the subject is a human.

9. The method of claim 1, wherein the salt is a tartrate salt.

10. The method of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is from about 0.001 mg to about 50 mg.

11. The method of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is from about 1 mg to about 10 mg.

12. The method of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is about 10 mg.

13. The method of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is about 25 mg.

14. The method of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is about 50 mg.

15. The method of claim 1, wherein the salt is a hydrochloride salt.
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