Details for Patent: 7,709,517

Title:	Diarylhydantoin compounds
Abstract:	The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Inventor(s):	Sawyers; Charles L. (New York, NY), Jung; Michael E. (Los Angeles, CA), Chen; Charlie D. (Los Angeles, CA), Ouk; Samedy (Costa Mesa, CA), Welsbie; Derek (Northridge, CA), Tran; Chris (New York, NY), Wongvipat; John (Nanuet, NY), Yoo; Dongwon (Los Angeles, CA)
Assignee:	The Regents of the University of California (Oakland, CA)
Filing Date:	May 15, 2006
Application Number:	11/433,829
Claims:	1. A compound selected from the group consisting of ##STR00238## 2. The compound of claim 1 having the formula ##STR00239## 3. The compound of claim 1, having the formula ##STR00240## 4. The compound of claim 1, having the formula ##STR00241## 5. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 2, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. 6. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 3, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. 7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 4, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. 8. A pharmaceutical acceptable salt of a compound according to claim 1. 9. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt of a compound of claim 1, and a pharmaceutically acceptable carrier or diluent. 10. A pharmaceutical composition according to claim 9, wherein the compound is dissolved. 11. A pharmaceutical composition according to claim 9, comprising a solvent. 12. A pharmaceutical composition according to claim 9 comprising one or more of dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water. 13. A pharmaceutical composition according to claim 9, dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water.