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|Title:||Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines|
|Abstract:||Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF.alpha. in a mammal.|
|Inventor(s):||Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)|
|Assignee:||Celgene Corporation (Summit, NJ)|
|Filing Date:||Apr 12, 2006|
|Claims:||1. A compound which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I or II, or an acid addition salt thereof: ##STR00007## wherein each of the (R) and (S) isomers has an optical purity of greater than 95 percent. |
2. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I.
3. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula II.
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