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Details for Patent: 7,709,502

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Details for Patent: 7,709,502

Title:Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines
Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF.alpha. in a mammal.
Inventor(s): Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)
Assignee: Celgene Corporation (Summit, NJ)
Filing Date:Apr 12, 2006
Application Number:11/401,858
Claims:1. A compound which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I or II, or an acid addition salt thereof: ##STR00007## wherein each of the (R) and (S) isomers has an optical purity of greater than 95 percent.

2. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I.

3. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula II.
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