Details for Patent: 7,709,502
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Title: | Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines |
Abstract: | Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF.alpha. in a mammal. |
Inventor(s): | Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ) |
Assignee: | Celgene Corporation (Summit, NJ) |
Filing Date: | Apr 12, 2006 |
Application Number: | 11/401,858 |
Claims: | 1. A compound which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I or II, or an acid addition salt thereof: ##STR00007## wherein each of the (R) and (S) isomers has an optical purity of greater than 95 percent. 2. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula I. 3. The compound of claim 1, which is a substantially chirally pure (R) or a substantially chirally pure (S) isomer of the compound of formula II. |