.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,709,012

« Back to Dashboard

Details for Patent: 7,709,012

Title:Ophthalmic compositions containing a synergistic combination of two polymers
Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of two polymers that have a synergistic effect on viscosity.
Inventor(s): Chowhan; Masood A. (Arlington, TX), Chen; Huagang (Irving, TX)
Assignee: Alcon, Inc. (Hunenberg, CH)
Filing Date:Jun 08, 2004
Application Number:10/863,169
Claims:1. An aqueous composition suitable for topical ophthalmic administration comprising a viscosity enhancing amount of combination of two polymers having a synergistic effect on the composition's viscosity and wherein the combination of two polymers is selected from the group consisting of hydroxypropyl methylcellulose and guar gum; a carboxyvinyl polymer and guar gum; hyaluronic acid and hydroxypropyl methylcellulose; and hyaluronic acid and guar gum, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid; wherein the aqueous composition has a viscosity that is greater than 150% of a sum of viscosities of two solutions, each of the two solutions respectively including only one of the two polymers and wherein the total concentration of the two polymers in the composition ranges from 0.2-2.0% (w/w) and wherein the composition does not gel upon administration to the eye.

2. The composition of claim 1 wherein the combination of two polymers is a combination of a hydroxypropyl methylcellulose and guar gum.

3. The composition of claim 1 wherein the combination of two polymers is a combination of a carboxyvinyl polymer and guar gum.

4. The composition of claim 1 wherein the combination of two polymers is a combination of hyaluronic acid and hydroxypropyl methylcellulose.

5. The composition of claim 1 wherein the combination of two polymers is a combination of hyaluronic acid and guar gum.

6. The composition of claim 1 wherein the carboxyvinyl polymer is a polymer of acrylic acid crosslinked with allyl sucrose or allylpentaerythritol, the hydroxypropyl methylcellulose has a number average molecular weight of approximately 86,000 dalton, the guar gum is hydroxypropyl guar.

7. The composition of claim 1 further comprising an ingredient selected from the group consisting of pharmaceutically acceptable buffering agents; preservatives; non-ionic tonicity-adjusting agents; surfactants; solubilizing agents; stabilizing agents; comfort-enhancing agents; emollients; pH-adjusting agents; and lubricants.

8. The composition of claim 1 further comprising an ophthalmic drug.

9. The composition of claim 8 wherein the ophthalmic drug is selected from the group consisting of anti-glaucoma agents; anti-angiogenesis agents; anti-infective agents; non-steroidal and steroidal anti-inflammatory agents; growth factors; immunosuppressant agents; and anti-allergic agents.

10. A method of alleviating the symptoms of dry eye comprising topically administering to the eye an aqueous composition comprising a viscosity enhancing amount of a combination of two polymers having a synergistic effect on the composition's viscosity and wherein the combination of two polymers is selected from the group consisting of hydroxypropyl methylcellulose and guar gum; a carboxyvinyl polymer and guar gum; hyaluronic acid and hydroxypropyl methylcellulose; and hyaluronic acid and guar gum, provided that if the composition comprises a carboxyvinyl polymer then the composition does not contain sodium chloride or boric acid; wherein the aqueous composition has a viscosity that is greater than 150% of a sum of viscosities of two solutions, each of the two solutions respectively including only one of the two polymers and wherein the total concentration of the two polymers in the composition ranges from 0.2-2.0% (w/w) and wherein the composition does not gel upon administration to the eye and wherein the composition alleviates symptoms of dry eye exhibited by the eye.

11. The method of claim 10 wherein the combination of two polymers is a combination of a hydroxypropyl methylcellulose and guar gum.

12. The method of claim 10 wherein the combination of two polymers is a combination of a carboxyvinyl polymer and guar gum.

13. The method of claim 10 wherein the combination of two polymers is a combination of hyaluronic acid and hydroxypropyl methylcellulose.

14. The method of claim 10 wherein the combination of two polymers is a combination of hyaluronic acid and guar gum.

15. The method of claim 10 wherein the carboxyvinyl polymer is a polymer of acrylic acid crosslinked with allyl sucrose or allylpentaerythritol, the hydroxypropyl methylcellulose has a number average molecular weight of approximately 86,000 dalton, the guar gum is hydroxypropyl guar.

16. The method of claim 10 further comprising an ophthalmic drug.

17. The composition of claim 1 wherein the combination of two polymers is a combination of a hydroxypropyl methylcellulose and guar gum and the composition has a viscosity of at least 32 cps.

18. The composition of claim 1 wherein the combination of two polymers is a combination of a carboxyvinyl polymer and guar gum and the composition has a viscosity of at least 1273 cps.

19. The method of claim 10 wherein the combination of two polymers is a combination of a hydroxypropyl methylcellulose and guar gum and the composition has a viscosity of at least 32 cps.

20. The composition of claim 10 wherein the combination of two polymers is a combination of a carboxyvinyl polymer and guar gum and the composition has a viscosity of at least 1273 cps.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc