Details for Patent: 7,642,258
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Title: | Combination of brimonidine and timolol for topical ophthalmic use |
Abstract: | Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans. |
Inventor(s): | Chang; Chin-Ming (Tustin, CA), Beck; Gary J. (Fullerton, CA), Pratt; Cynthia C. (Mission Viejo, CA), Batoosingh; Amy L. (Mission Viejo, CA) |
Assignee: | Allergan, Inc. (Irvine, CA) |
Filing Date: | Aug 24, 2007 |
Application Number: | 11/844,476 |
Claims: | 1. A composition comprising 0.2% brimonidine (w/v) and 0.5% timolol (w/v), in a single composition. 2. The composition of claim 1 further comprising from 0.001% to 0.01% benzalkonium chloride. 3. The composition of claim 2 comprising about 0.005% benzalkonium chloride. 4. The composition of claim 1 wherein brimonidine is brimonidine tartrate and timolol is timolol maleate. 5. The composition of claim 1 which is useful for treating ocular hypertension. 6. The composition of claim 1 which is useful for treating glaucoma. 7. An article of manufacture comprising packaging material and a composition within said packaging material, wherein said composition comprises 0.2% brimonidine by weight and 0.5% timolol by weight, in a single composition, and wherein said packaging indicates that the composition is useful for treating glaucoma or ocular hypertension by twice a day topical administration of the composition to a person's eye. 8. The article of manufacture of claim 7 wherein the composition further comprises from 0.001% to 0.01% benzalkonium chloride. 9. The article of manufacture of claim 7 wherein the composition further comprises about 0.005% benzalkonium chloride. |