Details for Patent: 7,550,440
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Title: | Topical application of ivermectin for the treatment of dermatological conditions/afflictions |
Abstract: | Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin. |
Inventor(s): | Manetta; Vincent (Bordentown, NJ), Watkins; Gary R. (Piscataway, NJ) |
Assignee: | Galderma S.A. (Cham, CH) |
Filing Date: | Oct 24, 2005 |
Application Number: | 11/255,910 |
Claims: | 1. A regime or regimen for the treatment of rosacea, comprising topically applying onto the affected skin area of an individual in need of such treatment, the topical pharmaceutical emulsion which comprises: TABLE-US-00010 Ivermectin 1.00 Glycerol 4.0 Acrylate C10-30 alkyl acrylate 0.2 crosspolymer Methyl para-hydroxybenzoate 0.2 Disodium EDTA 0.05 Citric acid monohydrate 0.05 Isopropyl palmitate 4.0 Cetyl alcohol 3.5 Stearyl monostearate 2.5 Oleyl alcohol 2.0 Ceteareth-20 3.0 Sorbitan monostearate 2.0 Dimethicone 200 20 cs 0.5 Propyl para-hydroxybenzoate 0.1 Propylene glycol 2.0 Phenoxyethanol 1.0 10% sodium hydroxide qs pH Water qs 100 as % by weight relative to the total weight of the emulsion. 2. A regime or regimen for the treatment of rosacea, comprising topically applying onto the affected skin area of an individual in need of such treatment, the topical pharmaceutical emulsion which comprises: TABLE-US-00011 Ivermectin 1.4 Glycerol 4.0 Acrylate C10-30 alkyl acrylate 0.2 crosspolymer Methyl para-hydroxybenzoate 0.2 Disodium EDTA 0.05 Citric acid monohydrate 0.05 Isopropyl palmitate 4.0 Cetyl alcohol 3.5 Stearyl alcohol 2.5 Oleyl alcohol 2.0 Ceteareth-20 3.0 Sorbitan monostearate 2.0 Dimethicone 200 20 cs 0.5 Propyl para-hydroxybenzoate 0.1 Propylene glycol 2.0 Phenoxyethanol 1.0 10% sodium hydroxide qs pH Water qs 100 as % by weight relative to the total weight of the emulsion. 3. The topically applicable, stable pharmaceutical emulsion comprising: TABLE-US-00012 Ivermectin 1.00 Glycerol 4.0 Acrylate C10-30 alkyl acrylate 0.2 crosspolymer Methyl para-hydroxybenzoate 0.2 Disodium EDTA 0.05 Citric acid monohydrate 0.05 Isopropyl palmitate 4.0 Cetyl alcohol 3.5 Stearyl alcohol 2.5 Oleyl alcohol 2.0 Ceteareth-20 3.0 Sorbitan monostearate 2.0 Dimethicone 200 20 cs 0.5 Propyl para-hydroxybenzoate 0.1 Propylene glycol 2.0 Phenoxyethanol 1.0 10% sodium hydroxide qs pH Water qs 100 as % by weight relative to the total weight of the emulsion. 4. The topically applicable, stable pharmaceutical emulsion comprising: TABLE-US-00013 Ivermectin 1.4 Glycerol 4.0 Acrylate C10-30 alkyl acrylate 0.2 crosspolymer Methyl para-hydroxybenzoate 0.2 Disodium EDTA 0.05 Citric acid monohydrate 0.05 Isopropyl palmitate 4.0 Cetyl alcohol 3.5 Stearyl alcohol 2.5 Oleyl alcohol 2.0 Ceteareth-20 3.0 Sorbitan monostearate 2.0 Dimethicone 200 20 cs 0.5 Propyl para-hydroxybenzoate 0.1 Propylene glycol 2.0 Phenoxyethanol 1.0 10% sodium hydroxide qs pH Water qs 100 as % by weight relative to the total weight of the emulsion. |