Details for Patent: 7,544,799
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Title: | Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use |
Abstract: | The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-- 2-ylamino)phenyl]-benzamide of formula 1, which may be used for example for tumour therapy. ##STR00001## |
Inventor(s): | Zimmermann; Jurg (Basel, CH), Sutter; Bertrand (Hesingue, FR), Burger; Hans M (Allschwil, CH) |
Assignee: | Novartis AG (Basel, CH) |
Filing Date: | Sep 05, 2006 |
Application Number: | 11/515,997 |
Claims: | 1. A crystalline form of the monomethanesulfonic acid addition salt of a compound of formula I, ##STR00004## having non-needle-shaped crystals. 2. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which comprises at least 95% by weight crystals of the .beta.-modification. 3. A crystalline form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I, which shows on X-ray diffraction a peak at an angle of refraction 2theta of 20.degree., said peak having a relative line intensity of about 65% as compared to the most intense line in the diagram. 4. A pharmaceutical composition, comprising the crystal form according to claim 1 of the methanesulfonic acid addition salt of a compound of formula I and a pharmaceutically acceptable carrier. |