Details for Patent: 7,507,759
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Title: | Methods of using(+)-2-[1-(3-ethoxy-4methoxyphenyl)-2-methylsulfonylethyl]-- 4-acetylaminoisoindoline-1,3,-dione |
Abstract: | Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoin- doline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4. |
Inventor(s): | Muller; George W. (Bridgewater, NJ), Schafer; Peter H. (Somerset, NJ), Man; Hon-Wah (Princeton, NJ), Ge; Chuansheng (Belle Mead, NJ) |
Assignee: | Celgene Corporation (Summit, NJ) |
Filing Date: | Jun 29, 2007 |
Application Number: | 11/824,523 |
Claims: | 1. A method of treating erythema nodosum leprosum in leprosy, rhematoid spondylitis, hepatitis or congestive heart failure which comprises administering to a patient a therapeutically effective amount of stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione, or a pharmaceutically acceptable prodrug, or salt thereof. 2. The method of claim 1 further comprising administering to a patient in need of such treatment a therapeutically effective amount of an antihistamine, anti-inflammatory drug, non-steroid anti-inflammatory drug or steroid. 3. The method of claim 1 or 2 wherein the patient is a mammal. 4. The method of claim 1 or 2 wherein the stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione is administered parenterally, transdermally, mucosally, nasally, buccally, sublingually, or orally. 5. The method of claim 4 wherein the stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione is administered orally. 6. The method of claim 5 wherein the stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione is administered orally in a tablet or capsule form. 7. The method of claim 6 wherein the therapeutically effective amount is from about 1 mg to about 1000 mg per day. 8. The method of claim 7 wherein the therapeutically effective amount is from about 5 mg to about 500 mg per day. 9. The method of claim 8 wherein the therapeutically effective amount is from about 10 mg to about 200 mg per day. 10. The method of claim 8 wherein the therapeutically effective amount is from about 20 mg per day. 11. The method of claim 8 wherein the therapeutically effective amount is from about 20 mg twice daily. |