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Generated: August 23, 2017

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Title:Methods and compositions for deterring abuse of opioid containing dosage forms
Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
Inventor(s): Kumar; Vijai (Morris Plains, NJ), Dixon; David (Woodside, NY), Tewari; Divya (Suffern, NY), Wadgaonkar; Dilip B. (Suffern, NY)
Assignee: Acura Pharmaceuticals, Inc. (Palatine, IL)
Filing Date:Feb 27, 2007
Application Number:11/657,360
Claims:1. A therapeutic pharmaceutical composition comprising a mixture including: (a) at least one opioid analgesic agonistic to the mu-receptor selected from the group consisting of: alfentanil, buprenorphine, carfentanil, codeine, dezocine, diacetylmorphine, dihydrocodeine, dihydromorphine, fentanyl, hydrocodone, hydromorphone, .beta.-hydroxy-3-methylfentanyl, levo-.alpha.-acetylmethadol, lofentanil, methadone, morphine, oxycodone, oxymorphone, propoxyphene, remifentanil, sufentanil, tilidine, and tramadol; (b) at least one opioid analgesic agonistic to the kappa-receptor selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine; (c) gel-forming polyethylene oxide at about 3 to about 40 percent by weight; (d) at least one disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and (e) sodium lauryl sulfate at about 1 to 10 percent by weight.

2. The therapeutic pharmaceutical composition of claim 1, wherein the polyethylene oxide has an average molecular weight ranging from 300,000 to about 5,000,000.

3. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in unit dose form.

4. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

5. The therapeutic pharmaceutical composition of claim 1, wherein the analgesic is present in an amount of 0.5 to about 25 percent by weight.

6. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is hydrocodone or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

7. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is oxycodone or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

8. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is morphine or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

9. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is codeine or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

10. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is hydromorphone or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

11. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is propoxyphene or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

12. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is tramadol or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

13. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is selected from the group consisting of: alfentanil, buprenorphine, carfentanil, codeine, dezocine, diacetylmorphine, dihydrocodeine, dihydromorphine, fentanyl, hydrocodone, hydromorphone, .beta.-hydroxy-3-methylfentanyl, levo-.alpha.-acetylmethadol, lofentanil, methadone, morphine, oxycodone, oxymorphone, propoxyphene, remifentanil, sufentanil, tilidine, and tramadol or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is meperidine or a pharmaceutically acceptable salt thereof.

14. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is methadone or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is selected from the group consisting of: butorphanol, diprenorphine, etorphine, levorphanol, meperidine, nalbuphine, pentazocine, and pethidine or a pharmaceutically acceptable salt thereof.

15. The therapeutic pharmaceutical composition of claim 1, wherein the opioid analgesic agonistic to the mu-receptor is selected from the group consisting of: alfentanil, buprenorphine, carfentanil, codeine, dezocine, diacetylmorphine, dihydrocodeine, dihydromorphine, fentanyl, hydrocodone, hydromorphone, .beta.-hydroxy-3-methylfentanyl, levo-.alpha.-acetylmethadol, lofentanil, methadone, morphine, oxycodone, oxymorphone, propoxyphene, remifentanil, sufentanil, tilidine, and tramadol or a pharmaceutically acceptable salt thereof; and the opioid analgesic agonistic to the kappa-receptor is pentazocine or a pharmaceutically acceptable salt thereof.

16. The therapeutic pharmaceutical composition of claim 1, wherein the disintegrant comprises crosprovidone.

17. The therapeutic pharmaceutical composition of claim 7, wherein the disintegrant comprises crosprovidone.

18. A therapeutic pharmaceutical composition comprising a mixture including: (a) an opioid analgesic agonistic to the mu-receptor; (b) an opioid analgesic agonistic to the kappa-receptor; (c) gel-forming polyethylene oxide at about 3 to about 40 percent by weight; (d) at least one disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and (e) sodium lauryl sulfate at about 1 to 10 percent by weight.
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