.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,407,988

« Back to Dashboard

Details for Patent: 7,407,988

Title:Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
Abstract: This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (1) A is an aryl group; Q.sup.1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: --S(.dbd.O).sub.2NR.sup.1-- and --NR.sup.1S(.dbd.O).sub.2--; R.sup.1 is a sulfonamido substituent; and, Q.sup.2 is an acid leader group; with the proviso that if J is --S(.dbd.O).sub.2NR.sup.1--, then Q.sup.1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
Inventor(s): Kalvinsh; Ivars (Riga, LV), Loza; Einars (Riga, LV), Gailite; Vija (Riga, LV)
Assignee: Topotarget UK Limited (Abingdon, GB)
Filing Date:Sep 07, 2006
Application Number:11/516,620
Claims:1. A compound selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof: ##STR00391## wherein: A-Q.sup.1- is: ##STR00392## R.sup.1 is: hydrogen, C.sub.1-7alkyl, C.sub.3-20heterocyclyl, or C.sub.5-20aryl; and R.sup.Q2 is: a partially unsaturated aliphatic C.sub.2-7alkylene group, or a saturated aliphatic C.sub.2-7alkylene group.

2. A compound according to claim 1, wherein R.sup.Q2 is a partially unsaturated aliphatic C.sub.2-7alkylene group.

3. A compound according to claim 1, wherein R.sup.Q2 is a saturated aliphatic C.sub.2-7alkylene group.

4. A compound according to claim 1, wherein R.sup.Q2 is --CH.dbd.CH--.

5. A compound according to claim 1, wherein R.sup.Q2 is --(CH.sub.2).sub.2--.

6. A compound selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof: ##STR00393## wherein: A-Q.sup.1- is: ##STR00394## R.sup.1 is hydrogen, C.sub.1-7alkyl, C.sub.3-20heterocyclyl, or C.sub.5-20aryl.

7. A compound according to claim 6, wherein A-Q.sup.1- is: ##STR00395##

8. A compound according to claim 6, wherein A-Q.sup.1- is: ##STR00396##

9. A compound according to claim 7, wherein R.sup.1 is --H, -Me, or -Et.

10. A compound according to claim 8, wherein R.sup.1 is --H, -Me, or -Et.

11. A compound selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof: ##STR00397## wherein A-Q.sup.1- is: ##STR00398##

12. A compound according to claim 11, wherein A-Q.sup.1- is: ##STR00399##

13. A compound selected from a compound of the following formula and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof: ##STR00400##

14. A compound selected from compounds of the following formula and pharmaceutically acceptable salts and solvates thereof: ##STR00401## wherein A-Q.sup.1- is: ##STR00402##

15. A compound selected from a compound of the following formula and pharmaceutically acceptable salts and solvates thereof: ##STR00403##

16. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or diluent.

17. A pharmaceutical composition comprising a compound according to claim 6 and a pharmaceutically acceptable carrier or diluent.

18. A pharmaceutical composition comprising a compound according to claim 14 and a pharmaceutically acceptable carrier or diluent.

19. A pharmaceutical composition comprising a compound according to claim 15 and a pharmaceutically acceptable carrier or diluent.

20. A method inhibiting HDAC in a cell comprising said cell with an effective amount of a compound according to claim 1.

21. A method for the treatment of cancer comprising administering to a subject suffering from cancer a therapeutically-effective amount of a compound according to claim 1.

22. A method for the treatment of psoriasis comprising administering to a subject suffering from psoriasis a therapeutically-effective amount of a compound according to claim 1.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc