Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Method of producing FR901228|
|Abstract:||Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion ##STR00001##|
|Inventor(s):||Ueda; Satoshi (Osaka, JP), Watamoto; Yoko (Osaka, JP), Tsuboi; Masaru (Osaka, JP), Kanda; Munekazu (Osaka, JP), Higaki; Tomoji (Osaka, JP), Matsuda; Mitsunori (Osaka, JP)|
|Assignee:||Astellas Pharma, Inc. (Tokyo, JP)|
|Filing Date:||Aug 22, 2001|
|Claims:||1. A method of producing FR901228 which comprises culturing a producing strain for FR901228 represented by the following formula: ##STR00003## in a medium added with at least one amino acid selected from the group consisting of L-arginine, L-histidine, L-cystine and L-cysteine or salt thereon. |
2. A method according to claim 1, wherein the amino acid is L-cysteine.
3. A method according to claim 1, wherein the amino acid is added in a concentration of 2 to 30 mM with respect to a medium in a volume of 1 liter.
4. A method according to claim 2, wherein the amino acid is added in a concentration of 2 to 30 mM with respect to a medium in a volume of 1 liter.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.