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Generated: December 17, 2017

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Title:Pulmonary delivery of active fragments of parathyroid hormone
Abstract: Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dispersion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pulsatile concentration profile of the PTH in the host's serum. PTH fragment compositions include dry powder formulations having the PTH present in a dry bulking powder, liquid solutions or suspensions suitable for nebulization, and aerosol propellants suitable for use in a metered dose inhaler.
Inventor(s): Patton; John S. (San Carlos, CA)
Assignee: Nektar Therapeutics (San Carlos, CA)
Filing Date:Sep 18, 2002
Application Number:10/245,707
Claims:1. A therapeutic composition in solid dose form comprising a bulking agent and an N-terminal peptide fragment of parathyroid hormone (PTH) as a bioactive agent, wherein said composition is a powder suitable for administration by inhalation, said bulking agent is selected from the group consisting of sucrose, lactose, trehalose, dextran and maltotriose, and said powder has a particle size between 0.5 .mu.m to 5 .mu.m.

2. The composition according to claim 1, wherein said peptide fragment consists of the first 34 amino acids of SEQ ID NO: 1.

3. The composition according to claim 1, wherein said peptide fragment consists of the first 34 to 38 amino acids of SEQ ID NO: 1.

4. The composition according to claim 1, further comprising an additive to maintain or enhance chemical stability and physiological acceptability.

5. The composition according to claim 4, wherein the additive is a peptidase inhibitor.

6. The composition according to claim 4, wherein the additive is a chelating agent.
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