.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,141,235

« Back to Dashboard

Details for Patent: 7,141,235

Title:Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
Abstract: A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.
Inventor(s): Trevino; Leo A. (San Diego, CA), Schutt; Ernest George (San Diego, CA), Klein; David H. (Carlsbad, CA), Tarara; Thomas E. (San Diego, CA), Weers; Jeffry G. (San Diego, CA), Kabalnov; Alexey (San Diego, CA)
Assignee: Imcor Pharmaceutical Co. (San Diego, CA)
Filing Date:Aug 28, 2001
Application Number:09/941,395
Claims:1. A system for providing an ultrasound image of at least a part of an object or body comprising: an ultrasound imaging apparatus; a kit capable of producing a stabilized microbubble preparation, conprising an aqueous medium, a gas osmotic agent, at least one phospholipid surfactant having at least one acyl chain of at least 10 or more carbon atoms and at least a second surfactant, wherein upon the application of energy the phospholipid surrounds the gas osmotic agent to form a microbubble, wherein the gas osmotic agent is selected from the group consisting of perfluorobutane, perfluorocyclobutane, perfluoropentane, perfluorocyclopentane, perfluoromethylcyclobutane, perfluorohexane, perfluorocyclohexane, perfluoromethylcyclopentane, perfluorodimethylcyclobutane, perfluoroheptane, perfluorocycloheptane, perfluoromethylcyclohexane, perfluorodimethylcyclopentane, perfluorotrimethylcyclobutane, perfluorotriethylamine, perfluoropropane and perfluorohexane.

2. The system of claim 1 wherein the gas osmotic agent is selected from the group consisting of perfluoropropane and perfluorohexane.

3. The system of claim 1 wherein the kit further comprises a modifier gas selected from the group consisting of nitrogen, oxygen, carbon dioxide or mixtures thereof.

4. The system of claim 3 wherein the mixture of the gas osmotic agent and modifier gas is effective to stabilize the microbubble preparation.

5. The system of claim 3 wherein the modifier gas is air.

6. The system of claim 3 wherein the gas osmotic agent is perfluoropropane and the second gas is nitrogen.

7. The system of claim 1 wherein the aqueous solution contains sterile water.

8. The system of claim 1 wherein the microbubble further comprises air.

9. The system of claim 1 wherein the gas osmotic agent is perfluoropropane.

10. The system of claim 1 wherein the kit contains a head space containing perfluoropropane gas.

11. The system of claim 10 wherein the head space contains air.

12. The system of claim 1 wherein the energy applied is mechanical energy.

13. The system of claim 1 wherein the energy applied is sonic energy.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc