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Generated: September 26, 2017

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Title:Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
Abstract: Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
Inventor(s): Mueller; Alan L. (Salt Lake City, UT), Moe; Scott T. (Salt Lake City, UT)
Assignee: NPS Pharmaceuticals, Inc. (Salt Lake City, UT)
Filing Date:Mar 09, 2004
Application Number:10/797,355
Claims:1. A compound of Formula VIII: wherein: ##STR00360## Z is selected from the group consisting of --CH.sub.2CH.sub.2--, --CH.sub.2CH(CH.sub.3)--, --CH.dbd.CH--, --O--CH.sub.2--, --S--CH.sub.2--, --O--, and --S--; X.sup.1 and X.sup.2 are independently selected from the group consisting of --F, --CH.sub.3, --OH, and lower O-alkyl in the 1-, 3-, 7-, or 9-substituent positions; m can be 1 or 2; --NHR is selected from the group consisting of --NH.sub.2, --NHCH.sub.3, and --NHC.sub.2H.sub.5; R.sup.1 is selected from the group consisting of --H, alkyl, hydroxyalkyl, --OH, --O-alkyl, and --O-acyl; R.sup.2 is selected from the group consisting of --H, alkyl, hydroxyalkyl; and pharmaceutically acceptable salts and complexes thereof; wherein the compound is active at an NMDA receptor.

2. The compound of claim 1, wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of --H and alkyl.

3. The compound of claim 1, wherein Z is selected from the group consisting of --CH.sub.2CH.sub.2--, --CH.dbd.CH--, --O--CH.sub.2--, --O--, and --S--.

4. The compound of claim 1, wherein Z is selected from the group consisting of --CH.sub.2CH.sub.2--and --O--CH.sub.2--.

5. The compound of claim 2, wherein Z is selected from the group consisting of --CH.sub.2CH.sub.2--, --CH.dbd.CH--, --O--CH.sub.2--, --O--, and --S--.

6. The compound of claim 2, wherein Z is selected from the group consisting of --CH.sub.2CH.sub.2--and --O--CH.sub.2--.
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