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|Title:||Rapidly absorbed liquid compositions|
|Abstract:||The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a non-steroidal anti-inflammatory drug in a liquid form. A preferred embodiment employs pseudoephedrine and ibuprofen.|
|Inventor(s):||Gelotte; Cathy Klech (North Wales, PA), Hills; Joanna F. (Glenside, PA), Pendley, II; Charles E. (Abington, PA), Shah; Manoj N. (Norristown, PA)|
|Filing Date:||Jun 26, 2003|
|Claims:||1. A method for enhancing the absorption rate of a pharmaceutically acceptable amine into the blood of a human child comprising administering a stable suspension comprising (i) a phamnacologically effective dosage of a pharmaceutically acceptable amine and (ii) an effective amount of ibuprofen. |
2. The method of claim 1 wherein the amine is pseudoephedrine.
3. The method of claim 1 wherein the enhanced absorption is indicated by AUC 1 H (early drug exposure) that is at least about 10% higher than the early drug exposure of the same amine from a single-ingredient liquid.
4. method of claim 1 wherein the enhanced absorption is indicated by AUC 2 H (early drug exposure) that is at least about 10% higher than the early drug exposure of the same amine from a single-ingredient liquid.
5. The method of claim 1 wherein the enhanced absorption is indicated by a C MAX (maximum or peak concentration) that is at least about 10% greater than the C MAX of the same amine from a single-ingredient liquid.
6. The method of claim 1 wherein the amine is provided in a range from about 15 mg to about 60 mg per dosage unit.
7. The method of claim 1 wherein the ibuprofen is provided in an amount of from about 40 mg to about 800 mg per dosage unit.
8. The method of claim 6 wherein the ibuprofen is provided in an amount of from about 40 mg to about 800 mg per dosage unit.
9. The method of claim 1 wherein the amine is provided at about 15 milligrams per 5 mL and the ibuprofen is provided at about 100 milligrams per 5 mL.
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