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|Title:||Amino ceramide-like compounds and therapeutic methods of use|
|Abstract:||Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.|
|Inventor(s):||Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Menlo Park, CA)|
|Assignee:||The Regents of the University of Michigan (Ann Arbor, MI)|
|Filing Date:||Jan 09, 2002|
|Claims:||1. A method for treating a patient having a microbial or viral infection comprising the step of administering to the patient a therapeutically effective amount of a compound selected from the group consisting of D-t-3', 4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol and stereoisomers and pharmaceutically acceptable salts thereof, wherein the infection is characterized by binding of the microbe, the virus, or a toxin thereof to glycosphingolipids of the patient's cells. |
2. The method of claim 1, wherein the infection is due to E. Coli, influenza A, or a verotoxin-producing microorganism.
3. The method of claim 1, wherein compound is D-t-3', 4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, or a pharmaceutically-acceptable salt thereof.
4. The method of claim 1, wherein the compound is D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, or a pharmaceutically-acceptable salt thereof.