|Title:||Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors|
|Abstract:||Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.|
|Inventor(s):||Hirth; Bradford H. (Littleton, MA), Siegel; Craig (Woburn, MA)|
|Assignee:||Genzyme Corporation (Cambridge, MA)|
|Filing Date:||Jul 16, 2002|
|Claims:||1. A compound represented by the following structural formula: ##STR32## the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein: R.sub.4 is H.sub.2 or O; and R.sub.6 is represented by the following structural formula: ##STR33## wherein phenyl ring A is substituted or unsubstituted; or when R.sub.4 is H.sub.2, R.sub.6 can further be --H. |
2. The compound of claim 1 wherein phenyl ring A is unsubstituted.