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Details for Patent: 6,855,830

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Details for Patent: 6,855,830

Title: Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
Abstract:Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Inventor(s): Hirth; Bradford H. (Littleton, MA), Siegel; Craig (Woburn, MA)
Assignee: Genzyme Corporation (Cambridge, MA)
Filing Date:Jul 16, 2002
Application Number:10/197,227
Claims:1. A compound represented by the following structural formula: ##STR32## the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein: R.sub.4 is H.sub.2 or O; and R.sub.6 is represented by the following structural formula: ##STR33## wherein phenyl ring A is substituted or unsubstituted; or when R.sub.4 is H.sub.2, R.sub.6 can further be --H.

2. The compound of claim 1 wherein phenyl ring A is unsubstituted.
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