.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 6,809,107

« Back to Dashboard

Details for Patent: 6,809,107

Title: Neurotrophic pyrrolidines and piperidines, and related compositions and methods
Abstract:This invention provides compounds having the following general structures: ##STR1## This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
Inventor(s): Kanojia; Ramesh M. (Bridgewater, NJ), Jordan; Alfonzo D. (North Wales, PA), Reitz; Allen B. (Lansdale, PA), Macielag; Mark J. (Branchburg, NJ), Zhao; Boyu (Lansdale, PA)
Assignee: Ortho-McNeil Pharmaceutical, Inc. (Raritan, NJ)
Filing Date:Jun 14, 2000
Application Number:09/593,852
Claims:1. A compound having the structure ##STR243##

or a pharmaceutically acceptable salt thereof, wherein (a) R.sup.1 is selected from the group consisting of H, COCOR.sup.2, COOR.sup.3 and SO.sub.2 R.sup.3, (i) R.sup.2 being selected from the group consisting of C.sub.1-6 straight or branched alkyl, C.sub.1-6 straight or branched alkenyl, C.sub.5-7 cycloalkyl, 2-thienyl, 3-thienyl or phenyl, the phenyl having one to three substituents independently selected from the group consisting of H, lower alkyl, lower alkoxyl, hydroxyl and halogen, and (ii) R.sup.3 being phenylalkyl, wherein the phenyl has one to three substituents independently selected from the group consisting of H, lower alkyl, lower alkoxyl, hydroxyl and halogen; (b) ##STR244## is either a saturated five-membered nitrogen containing heterocyclic ring, said ring containing one nitrogen atom, or a benzo-fused saturated six-membered nitrogen containing heterocyclic ring; (c) ##STR245## is an oxazole, an oxadiazole or a thiazole; and (d) A is attached to a carbon of the five-membered heteroaromatic ring and is selected from the group consisting of COO(CH.sub.2).sub.m Ar, ##STR246## (such R.sup.1 being the same as or different than the R.sup.1 described in part (a)), CONR.sup.4 (CH.sub.2).sub.m Ar, and (CH.sub.2).sub.m O(CH.sub.2).sub.n Ar (wherein R.sup.1 cannot be COCOR.sup.2 or SO.sub.2 R.sup.3), (i) R.sup.4 being H or C.sub.1-4 alkyl; (ii) Ar being selected from the group consisting of 2-pyridyl, 3-pyridyl, and 4 pyridyl; (iii) m being 1-4; and (iv) n being 0-4.

2. The compound of claim 1 having the structure ##STR247##

3. The compound of claim 1 having the structure ##STR248##

4. The compound of claim 1 having the structure ##STR249##

5. The compound of claim 1 having the structure ##STR250##

wherein each R.sup.1 is either the same as, or different than, the other.

6. The compound of claim 5 having the structure ##STR251##

7. The compound of claim 5 having the structure ##STR252##

8. The compound of claim 5 having the structure ##STR253##

9. The compound of claim 5 having the structure ##STR254##

10. The compound of claim 5 having the structure ##STR255##

11. The compound of claim 5 having the structure ##STR256##

12. A compound having the structure ##STR257##

13. A method of treating in a subject, Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, amyotrophic lateral sclerosis, diabetic neuropathy or Bell's palsy, comprising administering to the subject a prophylactically effective amount of the compound of claim 1.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc