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Details for Patent: 6,740,308

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Details for Patent: 6,740,308

Title: Delivery of antihistamines through an inhalation route
Abstract:The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing antihistamines that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antihistamine. In a method aspect of the present invention, an antihistamine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antihistamine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antihistamine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antihistamine; and, b) a device that forms an antihistamine containing aerosol from the composition, for inhalation by the mammal.
Inventor(s): Rabinowitz; Joshua D. (Mountain View, CA), Zaffaroni; Alejandro C. (Atherton, CA)
Assignee: Alexza Molecular Delivery Corporation (Palo Alto, CA)
Filing Date:May 21, 2002
Application Number:10/153,831
Claims:1. A composition for delivery of an antihistamine comprising a condensation aerosol a) formed by volatilizing an antihistamine under conditions effective to produce a heated vapor of the antihistamine and condensing the heated vapor of the antihistamine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% antihistamine degradation products, and c) wherein the aerosol MMAD is less than 3 microns.

2. The composition according to claim 1, wherein the antihistamine is selected from the group consisting of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine.

3. The composition according to claim 2, wherein the condensation aerosol particles comprise less than 2.5 percent by weight of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine degradation products.

4. The composition according to claim 2, wherein the condensation aerosol particles comprise at least 90 percent by weight of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine.

5. The composition according to claim 4, wherein the condensation aerosol has a mass median aerodynamic diameter less than 2 microns.

6. The composition according to claim 5, wherein the condensation aerosol particles comprise at least 97 percent by weight of azatadine, brompheniramine, chlorpheniramine, cyproheptadine, loratadine, hydroxyzine, or pyrilamine.

7. A method of producing an antihistamine in an aerosol form comprising: a) volatilizing an antihistamine under conditions effective to produce a heated vapor of the antihistamine, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the antihistamine comprising less than 5% drug degradation products and an aerosol having an MMAD less than 3 .mu.m.

8. The method according to claim 7, wherein the antihistamine is selected from the group consisting of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine.

9. The method according to claim 7, wherein said volatilizing includes heating a thin layer which includes the antihistamine and which is on a solid support having the surface texture of a metal foil, to a temperature sufficient to volatilize the antihistamine from the thin layer.

10. The method according to claim 8, wherein the aerosol particles comprise less than 2.5 percent by weight of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine degradation products.

11. The method according to claim 8, wherein the aerosol particles comprise at least 90 percent by weigh of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine.

12. The method according to claim 11, wherein the aerosol has a mass median aerodynamic diameter less than 2 microns.

13. The method according to claim 12, wherein the aerosol particles comprise at least 97 percent by weight of azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine.

14. The method according to claim 10, wherein the thin layer which includes azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, loratadine, pyrilamine, hydroxyzine, or promethazine on said solid support surface has a thickness between 4.2 and 4.9 microns.

15. The method according to claim 7, wherein the aerosol particles are formed at a rate of greater than 0.5 mg/sec.

16. The method according to claim 7, wherein the antihistamine is in a free base form.
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