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Details for Patent: 6,682,716

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Details for Patent: 6,682,716

Title: Delivery of aerosols containing small particles through an inhalation route
Abstract:The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1.mu. for inhalation therapy. In a composition aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1.mu.. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200 nm, or 10 nm and 100 nm.
Inventor(s): Hodges; Craig C. (Walnut Creek, CA), Lloyd; Peter M. (Walnut Creek, CA), Mufson; Daniel (Napa, CA), Rogers; Daniel D. (Oakland, CA), Wensley; Martin J. (San Francisco, CA)
Assignee: Alexza Molecular Delivery Corporation (Palo Alto, CA)
Filing Date:May 13, 2002
Application Number:10/146,515
Claims:1. A composition for inhalation therapy, comprising an aerosol of vaporized drug condensed into particles, wherein said aerosol has a mass median aerodynamic diameter between 10 nm and 100 nm.

2. The composition according to claim 1, wherein the mass of the aerosol is at least 0.05 mg.

3. The composition according to claim 2, wherein the particles comprise at least 5 percent by weight of drug.

4. The composition according to claim 3, wherein the particles comprise less than 10 percent by weight of drug degradation products.

5. The composition according to claim 4, wherein the aerosol has a geometric standard deviation around the mass median aerodynamic diameter of less than 2.

6. The composition according to claim 5, wherein the drug is an antibiotic.

7. The composition according to claim 5, wherein the drug is an anticonvulsant.

8. The composition according to claim 5, wherein the drug is an antidepressant.

9. The composition according to claim 5, wherein the drug is an antiemetic.

10. The composition according to claim 5, wherein the drug is an antihistamine.

11. The composition according to claim 5, wherein the drug is an antiparkinsonian drug.

12. The composition according to claim 5, wherein the drug is an anxiolytic.

13. The composition according to claim 5, wherein the drug is a drug for erectile dysfunction.

14. The composition according to claim 5, wherein the drug is a drug for migraine headaches.

15. The composition according to claim 5, wherein the drug is a drug for the treatment of alcoholism.

16. The composition according to claim 5, wherein the drug is a drug for the treatment of addiction.

17. The composition according to claim 5, wherein the drug is a muscle relaxant.

18. The composition according to claim 5, wherein the drug is a non-steroidal anti-inflammatory.

19. The composition according to claim 5, wherein the drug is an opioid.

20. The composition according to claim 5, wherein the drug is an other analgesic.

21. The composition according to claim 5, wherein the drug is a stimulant.

22. The composition of claim 1 wherein the drug particles comprise at least 40 percent by weight of a drug.

23. The composition of claim 1 wherein the drug particles comprise at least 50 percent by weight of a drug.

24. A composition for inhalation therapy, comprising a condensation aerosol of drug, wherein the aerosol has a mass median aerodynamic diameter between 10 nm and 100 nm and the drug is characterized by a decomposition index of less than 0.15.

25. A composition for inhalation therapy, comprising an aerosol of condensation drug particles, wherein the aerosol has a mass median aerodynamic diameter between 10 nm and 100 nm, and is essentially devoid of solvents.
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