Details for Patent: 6,596,746

Title:	Cyclic protein tyrosine kinase inhibitors
Abstract:	Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Inventor(s):	Das; Jagabandhu (Mercerville, NJ), Padmanabha; Ramesh (Hamden, CT), Chen; Ping (Belle Mead, NJ), Norris; Derek J. (Trenton, NJ), Doweyko; Arthur M. P. (Long Valley, NJ), Barrish; Joel C. (Holland, PA), Wityak; John (Robbinsville, NJ)
Assignee:	Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:	Apr 13, 2000
Application Number:	09/548,929
Claims:	1. A compound of formula I or a salt thereof ##STR622## where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is aryl substituted with at least one group Z.sub.3 where Z.sub.3 is --Z.sub.4 --NZ.sub.7 Z.sub.8 where Z.sub.4 is a bond Z.sub.7 is hydrogen or alkyl and Z.sub.8 is heterocyclo-substituted alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--. 2. A compound of claim 1 wherein R.sub.1 is hydrogen or alkyl, R.sub.2 and R.sub.4 are independently hydrogen or alkyl, and R.sub.5 is aryl which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3. 3. A compound of formula I or a salt thereof ##STR623## where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is heteroaryl substituted with at least one group Z.sub.3 where Z.sub.3 is --Z.sub.4 --NZ.sub.7 Z.sub.8 where Z.sub.4 is a bond Z.sub.7 is hydrogen or alkyl and Z.sub.8 is heterocyclo-substituted alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z--.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--. 4. A compound of formula I or a salt thereof ##STR624## where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is heteroaryl substituted with at least one group Z.sub.3 where Z.sub.3 is alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--. 5. A compound of claim 4 wherein R.sub.1 is hydrogen or alkyl, R.sub.2 and R.sub.4 are independently hydrogen or alkyl, and R.sub.5 is aryl which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3. 6. A compound or salt thereof selected from the group consisting of: [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-trifluoromethyl-2-thiazolyl]c arbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-trifluoromethyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-phenyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-phenyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[phenylamino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,4-Dichlorophenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-phenyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[(2-Methoxy-6-methylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbami c acid 1,1-dimethylethyl ester; [4-Methyl-5-[[[3-methyl-4-(1-methylethyl)phenyl]amino]carbonyl]-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; [5-[[(4-Bromo-2,6-dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[[2-methyl-6-(1-methylethyl)phenyl]amino]carbonyl]-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,4-Dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(2-methylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[2-(1,1-Dimethylethyl)-4-methylphenyl]amino]carbonyl]-4-methyl-2-thiaz olyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2-Furanylmethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[3-Methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]-4-methyl-2-thiazo lyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(4-Cyclohexylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(Cyclohexylmethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,3-Dihydro-1H-indenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[(2,5-Dihydro-1H-pyrrol-1-yl)carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[(2,5-Dihydro-2,5-dimethyl-1H-pyrrol-1-yl)carbonyl]-4-methyl-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; 1-[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]- L-prolinamide; [5-[(4-Formyl-1-piperazinyl)carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-(1,4-Dioxa-8-azaspiro[4,5]decan-8-ylcarbonyl)-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [5-[[3-[(Diethylamino)carbonyl]-1-piperidinyl]carbonyl]-4-methyl-2-thiazoly l]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(octahydro-1-quinolinyl)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolecarboxylic acid 2-[(1,1-dimethylethoxy)carbonyl]hydrazide; [5-[[(4-Methoxyphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(4-methylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(1,2-Dimethylpropyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,2-Dimethylpropyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(2-propynylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(2-propenylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(methylphenylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(3,4,5-trimethoxyphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[2,6-Bis(1-methylethyl)phenyl]amino]carbonyl]-4-methyl-2-thiazolyl]car bamic acid 1,1-dimethylethyl ester; [5-[[[3-(1H-Imidazol-1-yl)propyl]amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [5-[[[(3,4-Difluorophenyl)methyl]amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; N-[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]- L-leucine methyl ester; 5-[[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl] amino]-4-oxopentanoic acid methyl ester; [5-[[[2-(Ethylthio)ethyl]amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[Bis(3-methylbutyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[Ethyl(1-methylethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolecarboxylic acid 2-[[(3,5-dichlorophenyl)amino]thioxomethyl]hydrazide; [5-[[Bis(2-ethoxyethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[3-[(trifluoroacetyl)amino]-1-pyrrolidinyl]carbonyl]-2-thiazol yl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,6-Dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(2,2-Dichloro-1-methylcyclopropyl)carbonyl]amino]-4-methyl-N-(2,4,6-tri methylphenyl)-5-thiazolecarboxamide; 2-[(Cyclohexylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[(2,5-Difluorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(5-Bromo-2-chlorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[(3-Cyanobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[4-(Acetylamino)benzoyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 4-Methyl-2-[[3-(trifluoromethyl)benzoyl]amino]-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[[2-(2-phenylethyl)benzoyl]amino]-N-(2,4,6-trimethylphenyl)-5-th iazolecarboxamide; 2-[(3,5-Dimethylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(4-Ethenylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[(4-Butylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[(4-pentylbenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; 4-Methyl-2-[(1-oxo-3-phenoxypropyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[(1-oxo-3-phenylpropyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[[3-(2-Methoxyphenyl)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[(2-naphthalenylacetyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[(Diphenylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[(2-Chloro-6-fluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[(2-methylphenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[[(3-Methoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[[(3,4-Dimethoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[(4-Chlorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[([1,1'-Biphenyl]-4-ylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[(1-oxo-4-phenylbutyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(2-Hydroxy-2-phenyl-1-oxopropyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[(2-Hydroxy-1-oxohexyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 4-Methyl-2-[[1-oxo-4-(2-thienyl)butyl]amino]-N-(2,4,6-trimethylphenyl)-5-th iazolecarboxamide; 4-Methyl-2-[(3-thienylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[(2-Benzofuranylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-4-pyrid inecarboxamide, N-oxide; 6-Chloro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl ]-3-pyridinecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-3-pyrid inecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-3-quino linecarboxamide; 4-Methyl-2-[[(4-nitrophenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[(2,4,6-trichlorobenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 4-Methyl-2-[[2-[[3-(trifluoromethyl)phenyl]amino]benzoyl]amino]-N-(2,4,6-tr imethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[4-(4-nitrophenyl)-1-oxobutyl]amino]-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[4-(methylsulfonyl)benzoyl]amino]-N-(2,4,6-timethylphenyl)-5-th iazolecarboxamide; 2-[(4-Heptylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; 2-[[(2,4-Difluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; (S)-2-[[2-(Dipropylamino)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 2-[(2-Biphenylenecarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[3-(3-Methoxyphenyl)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-N-(2,4,6-trimethylphenyl)-2-[[(2,4,6-trimethylphenyl)acetyl]amino] -5-thiazolecarboxamide; 4-Methyl-2-[(1-oxo-6-heptenyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[[(1,3-Benzodioxol-5-yl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[[2-(phenylmethoxy)phenyl]acetyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[(3-phenoxyphenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[(3,5-Dimethoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[4-[4-[Bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 4-[[4-[[[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]am ino]carbonyl]phenyl]amino]-4-oxobutanoic acid methyl ester; 4-Methyl-2-[[(phenysulfonyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[2-(Acetylamino)-1-oxohexyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[4-[(Dipropylamino)sulfonyl]benzoyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[(4-Cyclohexylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(4-Bromo-3-methylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[[(2,3-Difluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[[[4-(1-methylethyl)phenyl]acetyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[4-(1,1-Dimethylethyl)cyclohexyl]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; N,N-Dimethyl-N'-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thia zolyl]butanediamide; 2-[(1,6-Dioxohexyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[(Benzo[b]thiophen-2-ylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[(1-Adamantylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 4-Methyl-2-[[(4-methylcyclohexyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[(1,7-Dioxooctyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[2-(Acetylamino)-4-(ethylthio)-1-oxobutyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 1,5-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-1H-pyrazole-3-carboxamide; 2-[[[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]benzoic acid; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-6-benzo thiazolecarboxamide; 1-Ethyl-4-methyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-t hiazolyl]-1H-pyrazole-3-carboxamide; 4-Methyl-2-[[3-[(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methyl]benzoyl]ami no]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[(2-Furanylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[(4-Chlorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; [4-Methyl-5[[(2-nitrophenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [4-Methyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, phenyl methyl ester; Methyl [4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [4-Methyl-5-[[methyl(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carb amic acid, 1,1-dimethylethyl ester; [4-Methyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, methyl ester; [4-Ethyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,6-Dichlorophenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2-methyl-6-isopropylphenyl)-4-methyl-5-thiazolecarboxamide, trifluoroacetate (1:1); 2-(Benzoylamino)-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[(phenylcetyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; 2-[[(Acetylamino)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-6-thiazol ecarboxamide; 2-Amino-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarbothioamide; 2-[(4-Bromobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[(4-nitrobenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[(4-Cyanobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[[(5-nitro-2-furanyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 4-Methyl-2-[(2-thienylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 4-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]benzoic acid methyl ester; 2-[(5-Isoxazolylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[(3-Furanylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[[(2,4-Dimethyl-5-thiazolyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[[(4-Methoxy-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 4-Methyl-2-[[(5-nitro-3-thienyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[[4-[(4-Chlorophenyl)thio]-3-thienyl]carbonyl]amino]-4-methyl-N-(2,4,6-t rimethylphenyl)-5-thiazolecarboxamide; 2-[[(5-Chloro-4-methoxy-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 2-[[[2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-3-thienyl]carbonyl]amino]-4-me thyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(2-Acetyl-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[(methylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[[(phenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[[[(4-methylphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[[(phenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 4-Methyl-2-[[(propylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[(Cyclohexylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-t hiazolecarboxamide; 2-[[[(2-Chlorophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(3-Fluorophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(2,6-Dimethylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethyl phenyl)-5-thiazolecarboxamide; [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, phenyl ester; 4-Methyl-2-[[[(2-phenylethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide 2-[[(Hexylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[[[(1,1-Dimethylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[[[(3-Fluoro-4-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2-[[(Diethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[[[Bis(1-methylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[methyl(phenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[(methylphenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[(Cyclohexylmethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-phenylethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[(Cyclopropylmethyl)propylamino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methylcyclohexyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(4-methylcyclohexyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[(Cyclohexylmethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dihydro-1H-inden-1-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-tri methylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-naphthalenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide 2-[[[Bis(phenylmethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2,6-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-4-morpholinecarboxamide; 2-Ethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -1-piperidinecarboxamide; 1-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]-3-piperidinecarboxylic acid ethyl ester; 3,3-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-1-piperidinecarboxamide 1-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]-4-piperidinecarboxylic acid ethyl ester; 4-Methyl-2-[[[(3-methyl-2-pyridinyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide 4-Methyl-2-[[[1-(phenylmethyl)-4-piperidinyl]amino]carbonyl]amino]-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; Octahydro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazoly l]-1(2H)-quinolinecarboxamide; 3,4-Dihydro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazo lyl]-2(1H)-isoquinolinecarboxamide; 2-[[[(1,5-Dimethylhexyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-methylheptyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[(2-Fluorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Ethoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(3-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(4-Chlorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(4-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(2,2-Diphenylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide 2-[[[(2-Aminoethyl)phenylamino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[[2-(3-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(3,4-Dimethoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6- trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(4-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-phenylpropyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(Cyclohex-1-en-1-yl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-t rimethylphenyl)-5-thiazolecarboxamide; 2-[[[[4-(1,1-Dimethylethyl)cyclohexyl]amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Butoxypropyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(2-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Chloro-4-fluorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(Hexylmethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[[[1-(4-Chlorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(3-Chlorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(2-thienyl)ethyl]amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[[2-(2-Fluorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(2-pyridinyloxy)ethyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Bromo-4,5-dimethoxyphenyl)methyl]methylamino]carbonyl]amino]-4-met hyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; (E)-2-[[[(3,7-Dimethyl-2,6-octadienyl)amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]amino]carbonyl]amino]-4-meth yl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[3-Methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]-4-methyl-N- (2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Cyclohexylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(5,6,7,8-tetrahydro-1-naphthalenyl)amino]carbonyl]amino]-N-(2 ,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(1-Anthracenylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[[[(4-Chloro-1-naphthalenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[(2-naphthalenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[[(1H-Indol-5-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[[(1,3-Benzodioxol-5-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide 4-Methyl-2-[[(2-pyrazinylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[[(5-Chloro-2-pyridinyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(6-methyl-2-pyridinyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methyl-4-quinolinyl)amino]carbonyl]amino]-N-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]carbonyl]amino]-4-methyl-N-(2, 4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[([1,1'-Biphenyl]-2-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxy-2-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide 4-Methyl-N-(2,4,6-trimethylphenyl)-2-[[[(2,4,6-trimethylphenyl)amino]carbon yl]amino]-5-thiazolecarboxamide; 2-[[[[2-(2-Hydroxyethyl)phenyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2-[[[(4-Methoxy[1,1'-biphenyl]-3-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Acetylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(4-Cyanophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[[4-Fluoro-2-(trifluoromethyl)phenyl]amino]carbonyl]amino]-4-methyl-N-( 2,4,6-trimethylphenyl)-5-thiazolecarboxamide 2-[[[(4-Hexyloxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 4-[[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino ]carbonyl]amino]benzoic acid ethyl ester; 2-[[[(4-Decylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[(4-propylphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide 4-Methyl-2-[[[(3,4,5-trimethoxyphenyl)amino]carbonyl]amino]-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]amino]carbo nyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 4-[[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino ]carbonyl]amino]benzoic acid butyl ester; 2-[[(1-Isoquinolinylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-[(phenylmethyl)thio]phenyl]amino]carbonyl]amino]-N-(2,4,6- trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[4-[(5-phenoxypentyl)oxy]phenyl]amino]carbonyl]amino]-N-(2,4, 6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[5-(1,1-Dimethylpropyl)-2-methoxyphenyl]amino]carbonyl]amino]-4-methyl -N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(1,2-Dihydro-5-acenaphthylenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-phenoxyphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide 4-Methyl-2-[[[[2-(4-morpholinyl)phenyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(1-piperidinyl)phenyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(1-Acetyl-2,3-dihydro-1H-indol-6-yl)amino]carbonyl]amino]-4-methyl-N-( 2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(2-Bromo-5-methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dimethyl-1H-indol-5-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-tr imethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-[[(1-methylethyl)amino]carbonyl]phenyl]amino]carbonyl]amin o]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Bromo-2-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxybutyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide 2-[[[(3,3-Dimethylbutyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methylbutyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-methylbutyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[(2-Methoxyethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(Dimethylamino)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(methylthio)ethyl]amino]carbonyl]amino]-N-(2,4,6-trimethyl phenyl)-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,3-dihydro-1H-inden-5-yl)-4-methyl-5-th iazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-2-naphthalenyl-4-methyl-5-thiazolecarboxa mide; 2-[[(Butylamino)carbonyl]amino]-N-(3-hydroxy-2-naphthalenyl)-4-methyl-5-thi azolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2-fluoro-5-methylphenyl)-4-methyl-5-thia zolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethylphenyl)-4-methyl-5-thiazolec arboxamide; N-(3-Bromo-2,4,6-trimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl- 5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[2,6-dimethyl-3-(1-methylethyl)phenyl]-4- methyl-5-thiazolecarboxamide N-(2-Bromo-4,6-dimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-t hiazolecarboxamide; 3-[[[2-[[(Butylamino)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]amino]-4 -methyl-2-thiophenecarboxylic acid methyl ester; 2-[[(Butylamino)carbonyl]amino]-4-methyl-N-(2-methyl-6-quinolinyl)-5-thiazo lecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethoxyphenyl)-4-methyl-5-thiazole carboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(4-methoxy-2-naphthalenyl)-4-methyl-5-thi azolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2-methyl-1-naphthalenyl)-4-methyl-5-thia zolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[4-(dimethylamino)-2,3,5,6-tetramethylphe nyl]-4-methyl-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(6-methyl-5-quinolinyl)-4-methyl-5-thiazo lecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[2-(2-hydroxyethyl)-6-methylphenyl]-4-met hyl-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethyl-3-nitrophenyl)-4-methyl-5-t hiazolecarboxamide; N-(2-Bromo-3,4,6-trimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl- 5-thiazolecarboxamide; N-(2-Acetyl-6-hydroxyphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-thi azolecarboxamide; [4-[[[2-[[(Butylamino)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]amino]- 2,3,5,6-tetramethylphenyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dichlorophenyl)-4-methyl-5-thiazolec arboxamide; N-(4-Amino-2,3,5,6-tetramethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-met hyl-5-thiazolecarboxamide; N-[5-(Acetylamino)-2,4-dimethylphenyl]-2-[[(butylamino)carbonyl]amino]-4-me thyl-5-thiazolecarboxamide; N-(4-Bromo-2,6-dimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-t hiazolecarboxamide 2-[[(Butylamino)carbonyl]amino]-N-(2-chloro-6-methylphenyl)-4-methyl-5-thia zolecarboxamide; 4-Methyl-2-[(methylsulfonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[[(phenylamino)thiocarbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-t hiazolecarboxamide; 2-[[(Ethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-5-thiazolecarbox amide; 2-[[[(1,1-Dimethylethyl)amino]carbonyl]amino]-N-(2-chloro-6-methylphenyl)-5 -thiazolecarboxamide; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazoleacetamide; 2-Amino-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleacetamide; N-(2-Chloro-6-methylphenyl)-2-[(4,6-dimethyl-2-pyridinyl)amino]-5-thiazolec arboxamide; N-(2-Chloro-6-methylphenyl)-2-[(4-ethyl-2-pyridinyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimdinyl)amino]-5-thiazole carboxamide; N-(2-Chloro-6-methylphenyl)-2-(3-pyridazinylamino)-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(2-thienylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-4-methyl-5-thiaz olecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(2-furanylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(3-thienylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(3-furanylcarbonyl)amino]-5-thiazol ecarboxamide; trans-N(-Chloro-6-methylphenyl)-4-methyl-2-[[(2-phenylcyclopropyl)carbonyl] amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[[(2-methylcyclopropyl)carbonyl]amin o]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclobutylcarbonyl)amino]-4-methyl-5-thiazo lecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopentylcarbonyl)amino]-4-methyl-5-thiaz olecarboxamide; 2-(Benzoylamino)-N-(2-chloro-6-methylphenyl)-4-methyl-5-thiazolecarboxamide ; N-(2-Chloro-6-methylphenyl)-2-[(1-oxopropyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(1-oxobutyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-ethyl-1-oxobutyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[[(1-phenylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-methylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2,2-dichloro-1-methylcyclopropyl)carbonyl] amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2-methylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-hydroxycyclopropyl)carbonyl]amino]-5-thi azolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]am ino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-cyanocyclopropyl)carbonyl]amino]-5-thiaz olecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclobutylcarbonyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopentylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(cyclohexylcarbonyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[(phenylacetyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclohexylacetyl)amino]-5-thiazolecarboxami de; N-(2-Chloro-6-methylphenyl)-2-[(4-pyridinylacetyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[[(2,5-dimethyl-1H-pyrrol-3-yl)carbonyl]amino ]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(3-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(4-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(3-thienylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(2-thienylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(2-furanylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(3-furanylcarbonyl)amino]-5-thiazolecarboxam ide; trans-N-(2-Chloro-6-methylphenyl)-2-[[(2-phenylcyclopropyl)carbonyl]amino]- 5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-methyl-1-oxopentyl)amino]-5-thiazolecarbo xamide; 2-(Benzoylamino)-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide; 2-[(Cyclopropylcarbonyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide ; 2-[(Cyclopropylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxam ide; N-(2-Chloro-4,6-dimethylphenyl)-2-[(cyclopropylcarbonyl)amino]-5-thiazoleca rboxamide; [4-[2-Oxo-2-[(2,4,6-trimethylphenyl)amino]ethyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-thiazoleacetamide; 5-Amino-2-methyl-N-(2,4,6-trimethylphenyl)benzamide; 2-Amino-5-chloro-N-(2,4,6-trimethylphenyl)-4-pyrimidinecarboxamide; [4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-oxazolyl]carbamic acid 1,1-dimethylethyl ester; 2-Amino-4-(methyl)-N-(2,4,6-trimethylphenyl)-5-oxazolecarboxamide, trifluoroacetate (1:1); 2-Amino-N-(2,4,6-trimethylphenyl)-5-pyridinecarboxamide; 3-Amino-N-(2,4,6-trimethylphenyl)-4-pyridinecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; 2-[(6-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-4-pyrimidinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(5-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; '2-[(5-Bromo-3-methyl-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thia zolecarboxamide; '2-[(6-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; '2-[(5-Bromo-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(phenylmethoxy)-2-pyridinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(5-chloro-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; '2-[(3-Bromo-5-methyl-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thia zolecarboxamide; '2-[(2-Amino-3-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; '2-[(3-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-(4-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(3-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-3-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(2-chloro-3-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-methoxy-3-pyridinyl)amino]-5-thiazolecar boxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3,5-dimethyl-2-pyrazinyl)amino]-5-thiazole carboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(phenylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3-ethylphenyl)amino]-5-thiazolecarboxamide ; 'N-(2-Chloro-6-methylphenyl)-2-[(3,5-dimethylphenyl)amino]-5-thiazolecarbox amide; 'N-(2-Chloro-6-methylphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)amino]-5-thiazo lecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-4-pyrimidinyl)amino]-5-thiazolecar boxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-pyrazinyl)amino]-5-thiazolecarb oxamide; '2-[(3-Aminophenyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ; 'N-(2-Chloro-6-methylphenyl)-2-[(3-hydroxyphenyl)amino]-5-thiazolecarboxami de; '2-[(3-Bromophenyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ; 'N-(2,6-Dimethylphenyl)-2-(phenylamino)-5-thiazolecarboxamide; 'N-(2,6-Dimethylphenyl)-2-(methylphenylamino)-5-thiazolecarboxamide; 'N-(2,6-Dimethylphenyl)-2-(2-pyridinylamino)-5-thiazolecarboxamide; 'N-(2,6-Dimethylphenyl)-2-[(6-methyl-2-pyridinyl)amino]-5-thiazolecarboxami de; 'N-(2,6-Dimethylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarboxami de; 'N-(2,6-Dimethylphenyl)-2-[(4-ethyl-2-pyridinyl)amino]-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(4,6-dimethyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; '2-[(6-Amino-2-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(6-ethyl-2-pyridinyl)amino]-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarboxami de; '2-[(2-Amino-3-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; '2-[(3-Amino-2-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; '2-[(6-Amino-2-methyl-4-pyrimidinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazol ecarboxamide; 'N-(2,6-Dimethylphenyl)-2-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-5-thiazo lecarboxamide; '2-[(6-Chloro-3-pyridazinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxa mide; 'N-(2,6-Dimethylphenyl)-2-(3-pyridazinylamino)-5-thiazolecarboxamide; '2-[(3-Aminophenyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide; '2-[(3-Bromophenyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide; '2-(2-Pyridinylamino)-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; '2-[(6-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(5-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thialzolecarbo xamide; '2-[(4-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(3-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(5-Bromo-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(5-Chloro-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(6-Methoxy-3-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbo xamide; '2-[(4-Ethyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(6-Ethyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(6-Chloro-3-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(2,6-Dimethyl-4-pyrimidinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazole carboxamide; '2-[(4-Methyl-2-pyrimidinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; '2-(2-Pyrazinylamino)-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide '2-[(6-Chloro-2-pyrazinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(3,5-Dimethyl-2-pyrazinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(4-morpholinyl)ethyl]amino] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[3-(4-morpholinyl)propyl]amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methyl phenyl)-2-[[2-methyl-6-[methyl[3-(methylamino)propyl]amino]-4-pyrimidinyl] amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(tetrahydro-2-oxo-1H-imidaz ol-1-yl)ethyl]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[(2-1H-imidazol-4-ylethyl)amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(4-morpholinyl)-4-pyrimidinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[(2R)-1-ethyl-2-pyrrolidinyl]methyl]am ino]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]am ino]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; '2-[[6-[(2S)-2-(Aminocarbonyl)-1-pyrrolidinyl]-2-methyl-4-pyrimidinyl]amino ]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-hydroxyethyl)amino]-2-methyl-4-pyrim idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(hydroxymethyl)-1-piperidinyl]-2-meth yl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-met hyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; '1-[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-2-m ethyl-4-pyrimidinyl]-4-piperidinecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[(3S)-3-methyl-1-piperazinyl]-4 -pyrimidinyl]amino]-5-thiazolecarboxamide; '2-[[6-[3-(Acetylamino)-1-pyrrolidinyl]-2-methyl-4-pyrimidinyl]amino]-N-(2- chloro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-methyl-2-pyrrolidinyl)ethyl]amino ]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)methyl] amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(1H-1,2,3-triazol-1-yl)ethy l]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-4-pyrimi dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(dimethylamino)ethyl]amino]-4-pyrimi dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-7-[[6-[[2-(tetrahydro-2-oxo-1H-imidazol-1-yl)e thyl]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[methyl[2-(methylamino)ethyl]amino]-4-py rimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-methyl-2-pyrrolidinyl)ethyl]amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-pyrrolidinyl)ethyl]amino]-4-pyrim idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(1-ethyl-2-pyrrolidinyl)methyl]amino]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(4-piperidinylmethyl)amino]-4-pyrimidin yl]amino]-5-thiazolecarboxamide; '2-[[6-[[2-(Acetylamino)ethyl]amino]-4-pyrimidinyl]amino]-N-(2-chloro-6-met hylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1H-1,2,3-triazol-1-yl)ethyl]amino]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-4-pyrimidinyl]amino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-2-pyridi nyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(4-morpholinyl)propyl]amino]-2-pyrid inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[methyl [3-(methylamino)propyl]amino]-2-pyridinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3S)-3-methyl-1-piperazinyl]-2-pyridiny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3-1H-imidazol-1-ylpropyl)amino]-2-pyri dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-hydroxyethyl)amino]-2-pyridinyl]amin o]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-1H-imidazol-1-ylethyl)amino]-2-pyrid inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-2-pyridinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-2-pyrazi nyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(4-morpholinyl)propyl]amino]-2-pyraz inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-2-pyrazinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3S)-3-methyl-1-piperazinyl]-2-pyraziny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(3-hydroxy-1-pyrrolidinyl)-2-pyrazinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(1H-imidazol-1-yl)-2-pyrazinyl]amino]-5- thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(3-hydroxy-1-pyyrolidinyl)-3-pryidazinyl ]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(1H-imidazol-1-yl)-3-pyridazinyl]amino]- 5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(methylamino)-2-pyrazinyl]amino]-5-thiaz olecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(3-hydroxy-1-pyrrolidinyl)-2-pyrazinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(cyclopropylamino)-2-pyrazinyl]amino]-5- thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(4-morpholinyl)-2-pyrazinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-[[2-(4-morpholinyl)ethyl]amino]-2-pyrazi nyl]amino]-5-thiazolecarboxamide; '2-[[3-[[2-(Acetylamino)ethyl]amino]-2-pyrazinyl]amino]-N-(2-chloro-6-methy lphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(cyclohexylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(methylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(cyclopropylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(phenylmethyl)amino]-5-thiazolecarboxamide; '2-[[2-(Acetylamino)ethyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino ]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(methoxymethyl)-4-pyrimidinyl]amino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-hydroxymethyl)-4-pyrimidinyl]amino]-5-th iazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinylmethyl)-4-pyrimidinyl]amin o]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(dimethylamino)-ethyl]amino]methyl] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(4-morpholinyl)ethyl]amino]methyl]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[3-(4-morpholinyl)propyl]-amino]methyl ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[3-(2-oxo-1-pyrrolidinyl)propyl]amino] methyl]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(2-1H-imidazol-4-ylethyl)amino]methyl] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(3-1H-imidazol-1-ylpropyl)amino]methyl ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(2-pyridinyl)ethyl]amino]methyl]-4- pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(3-pyridinyl)ethyl]amino]methyl]-4- pyrimidinyl]amino]-5-thiazolecarboxamide; '1-[[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-4- pyrimidinyl]methyl]-4-piperidinecarboxamide; '2-[[6-[[[2-(Acetylamino)ethyl]amino]methyl]-4-pyrimidinyl]amino]-N-(2-chlo ro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-naphthalenylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-quinolinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(3-isoquinoliny