Details for Patent: 6,509,327

Title:	Compositions and methods for treating otic, ophthalmic and nasal infections
Abstract:	Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
Inventor(s):	Cagle; Gerald (Fort Worth, TX), Abshire; Robert L. (Fort Worth, TX), Stroman; David W. (Irving, TX), McLean; Celeste H. (Fort Worth, TX), Clark; Linda L. (Grandview, TX), Yanni; John M. (Burleson, TX)
Assignee:	Alcon Manufacturing, Ltd. (Fort Worth, TX)
Filing Date:	May 19, 2000
Application Number:	09/575,850
Claims:	1. A method of treating acute otitis externa infections attributable to a pathogenic Microbacterium species selected from the group consisting of Microbacterium otitidis and Microbacterium alconae, which comprises instilling a therapeutically effective amount of an antibiotic composition in the affected ear to eradicate said pathogenic Microbacterium species, said composition comprising an antimicrobial effective amount of a third generation quinolone antibiotic and a pharmaceutically acceptable vehicle therefor. 2. A method according to claim 1, wherein the third generation quinolone antibiotic comprises moxifloxacin. 3. A method according to claim 1, wherein the composition further comprises an effective amount of an anti-inflammatory compound. 4. A method according to claim 3, wherein the anti-inflammatory compound comprises dexamethasone. 5. A method according to claim 4, wherein the third generation quinolone antibiotic comprises moxifloxacin.