.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 6,384,016

« Back to Dashboard

Details for Patent: 6,384,016

Title: Stabilized aqueous peptide solutions
Abstract:Aqueous compositions comprising at least one peptide selected from glucagon, GLP-1, and analogues and derivatives thereof together with a stabilizing and solubilizing amount of at least one detergent, said detergent having at least 2 positive charges, at least 2 negative charges, or a combination of at least one positive charge and at least one negative charge.
Inventor(s): Kaarsholm; Niels C. (Vanl.o slashed.se, DK)
Assignee: Novo Nordisk A/S (Bagsvaerd, DK)
Filing Date:Mar 08, 1999
Application Number:09/265,141
Claims:1. A stabilized aqueous composition comprising at least one peptide selected from the group consisting of glucagon, glucagon-like peptide-1 (GLP-1), and analogues and derivatives thereof, together with a stabilizing and solubilizing amount of at least one detergent, wherein the detergent has at least 2 positive charges, at least 2 negative charges, or a combination of at least one positive charge and at least one negative charge, the peptide being present in a concentration of about 0.1-10 mg/ml, with the proviso that the detergent is not dodecyl phosphocholine, and wherein a stabilizing and solubilizing detergent is selected from the group consisting of (i) a 1-acyl-sn-glycero-3-phosphate ester of ethanolamine, choline, serine or threonine; and (ii) lauroyl lysophosphotidylcholine or myristoyl lysophosphatidylcholine.

2. The composition of claim 1 comprising about 0.5-2.5 mg of peptide per ml and about 1-5 mM of lauroyl or myristoyl lysophosphatidylcholine.

3. The composition of claim 1, further comprising at least one compound selected from the group consisting of an isotonic agent, a buffer substance buffering at pH 4-8, and a preservative.

4. The composition of claim 1, wherein the peptide is present in a concentration of about 0.2-5 mg/ml.

5. The composition of claim 4, wherein the peptide is present in a concentration of about 0.5-3 mg/ml.

6. The composition of claim 1, wherein the detergent is present in an amount of about 0.3-40 moles of detergent per mole of peptide.

7. The composition of claim 6, wherein the detergent is present in an amount of about 0.5-30 moles of detergent per mole of peptide.

8. The composition of claim 7, wherein the detergent is present in an amount of about 1-20 moles of detergent per mole of peptide.

9. A method for stabilizing an aqueous composition comprising at least one peptide selected from the group consisting of glucagon, glucagon-like peptide -1 (GLP-1), and analogues and derivatives thereof, wherein the peptide is present in a concentration of at least about 0.1 mg/ml, the method comprising adding to said composition a stabilizing and solubilizing amount of at least one detergent, wherein the detergent has at least 2 positive charges, at least 2 negative charges, or a combination of at least one positive charge and at least one negative charge, with the proviso that the detergent is not dodecyl phosphocholine, wherein the at least one peptide is stabilized in the aqueous composition, and wherein the detergent is selected from the group consisting of (i) a 1-acyl-sn-glycero-3-phosphate ester of ethanolamine, choline, serine or threonine and (ii) lauroyl lysophosphotidylcholine or myristoyl lysophosphatidylcholine.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc