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|Title:||Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis|
|Abstract:||Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.|
|Inventor(s):||von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD)|
|Assignee:||Pro-Neuron, Inc. (Rockville, MD)|
|Filing Date:||Jun 05, 1995|
|Claims:||1. A method for treating cancer consisting essentially of administering to an animal a therapeutically effective amount of a therapeutic cytokine or inflammatory stimulus and a therapeutically effective amount of a pyrimidine nucleotide precursor prior to, during, or after administration of said cytokine or said stimulus, wherein said pyrimidine nucleotide precursor is a pyrimidine nucleoside or prodrug thereof. |
2. A method as in claim 1 wherein said pyrimidine nucleotide precursor is uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof.
3. A method as in claim 2 wherein said acyl derivative of uridine is triacetyluridine.
4. A method as in claim 1 wherein said cytokine or said stimulus is selected from the group consisting of interleukin 1, interleukin-2, interleukin 6, tumor necrosis factor, endotoxin, fungal polysaccharides, and double-stranded RNA.
5. A method as in claim 1 further comprising the step of administering an inhibitor of uridine phosphorylase.
6. A method for treating cancer comprising administering to an animal a therapeutically effective amount of a therapeutic cytokine or inflammatory stimulus and a therapeutically effective amount of an inhibitor of uridine phosphorylase prior to, during, or after administering said cytokine or said stimulus.
7. A method as in claim 6 wherein said cytokine or said stimulus is selected from the group consisting of interleukin 1, interleukin-2, interleukin 6, tumor necrosis factor, endotoxin, fungal polysaccharides, and double-stranded RNA.
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