Details for Patent: 6,307,052

Title:	Acid-addition salts of optically active piperidine compound and process for producing the same
Abstract:	The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-[4-[(4-chlorophenyl) (2-pyridyl)methoxy]piperidino]butanoic acid represented by the formula (I): ##STR1## wherein * represents an asymmetric carbon, which are excellent in antihistaminic activity and anti-allergic activity, and a process for producing the same.
Inventor(s):	Kita; Jun-ichiro (Ube, JP), Fujiwara; Hiroshi (Ube, JP), Takamura; Shinji (Ube, JP), Yoshioka; Ryuzo (Osaka, JP), Ozaki; Yasuhiko (Osaka, JP), Yamada; Shin-ichi (Takarazuka, JP)
Assignee:	Ube Industries, Ltd. (Yamaguchi, JP) Tanabe Seiyaku Co., Ltd. (Osaka, JP)
Filing Date:	Jun 25, 1999
Application Number:	09/331,792
Claims:	1. A process for preparing a benzenesulfonic acid salt or a benzoic acid salt of the optically active piperidine compound represented by formula (I) ##STR13## which comprises reacting (.+-.)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]-piperidine with an optically active propionic acid compound represented by the formula (VII): ##STR14## wherein Y represents a hydrogen atom or a halogen atom; Z represents a lower alkoxy group; and * represents an asymmetric carbon, or an optically active N-acyl-amino acid; separating and collecting a less soluble diastereomeric salt by utilizing the difference in solubilities of the formed two kinds of diastereomeric salts; decomposing the resulting salt; reacting the resulting (S)-4-[4-chlorophenyl)(2- pyridyl)methoxy]piperidine with an ester represented by the formula (V): ##STR15## wherein R represents a lower alkyl group, and W represents a leaving group such as a halogen atom and a reactive ester group, to obtain (S)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butanoic acid ester represented by the formula (VI): ##STR16## wherein R and * have the same meaning as defined above; hydrolyzing the resulting compound; and reacting the hydrolyzed compound with benzenesulfonic acid or benzoic acid to form a salt. 2. A process for preparing an optically active piperidine intermediate represented by the formula (IV): ##STR17## wherein * represents an asymmetric carbon, which comprises reacting a racemic piperidine compound represented by the formula (III): ##STR18## with an optically active propionic acid compound represented by the formula (VII): ##STR19## wherein Y represents a hydrogen atom or a halogen atom; Z represents a lower alkoxy group; and * has the same meanings as defined above, or an optically active N-acyl-amino acid; separating and collecting one of the diastereomeric salts by utilizing the difference in solubilities of the formed two kinds of diastereomeric salts; and decomposing the resulting salt.