Details for Patent: 6,284,804
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Title: | Topical suspension formulations containing ciprofloxacin and dexamethasone |
Abstract: | Suspension formulations containing dexamethasone and ciprofloxacin are disclosed. The formulations contain a nonionic polymer, a nonionic surfactant and an ionic tonicity agent, but are physically stable and easily re-suspended. The formulations are intended for topical application to the eye, ear or nose. |
Inventor(s): | Singh; Onkar N. (Arlington, TX), Bhagat; Haresh G. (Fort Worth, TX) |
Assignee: | Alcon Universal Ltd. (Hunenberg, CH) |
Filing Date: | Aug 10, 2000 |
Application Number: | 09/636,563 |
Claims: | 1. A topically administrable suspension composition intended for application to the eye, ear or nose consisting essentially of a) 0.1% (wt.) dexamethasone alcohol; b) 0.35% (wt.) ciprofloxacin hydrochloride, monohydrate; c) NaCI in an amount sufficient to cause the composition to have an osmolality of about 250-350 mOsm; d) 0.2% (wt.) hydroxyethyl cellulose; e) 0.05% (wt.) tyloxapol; f) a buffer comprising sodium acetate and acetic acid; g) 0.01% (wt.) benzalkonium chloride; h) 0.01% (wt.) edetate disodium; i) 0.6% (wt.) boric acid; and wherein the composition has a pH of 4.5.+-.0.2. |