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Details for Patent: 6,255,336

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Details for Patent: 6,255,336

Title: Amino ceramide-like compounds and therapeutic methods of use
Abstract:Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Inventor(s): Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Menlo Park, CA)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Filing Date:Jul 09, 1999
Application Number:09/350,768
Claims:1. A compound wherein the compound is D-t-3',4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol or pharmaceutically acceptable salts thereof.

2. A compound wherein the compound is D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol or pharmaceutically acceptable salts thereof.

3. A composition comprising a carrier and a compound selected from the group consisting of D-t-3',4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol , D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, pharmaceutically acceptable salts thereof and mixtures thereof.

4. The composition of claim 3, wherein the compound is D-t-3',4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol .

5. The composition of claim 3, wherein the compound is a pharmaceutically acceptable salt of D-t-3',4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol .

6. The composition of claim 3, wherein the compound is D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol.

7. The composition of claim 3, wherein the compound is a pharmaceutically acceptable salt of D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol.

8. A method for treating a patient having sphingolipidosis by reducing glycosphingolipid synthesis comprising the step of administering to the patient a therapeutically effective amount of a compound selected from the group consisting of D-t-3',4'-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol , D-t-4'-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, pharmaceutically acceptable salts thereof and mixtures thereof.

9. The method of claim 8, wherein the patient is diagnosed as having Gaucher disease.

10. The method of claim 8, wherein the patient is diagnosed as having Tay-Sachs disease.

11. The method of claim 8, wherein the patient is diagnosed as having Fabry disease.
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