|Title:|| Process for the preparation of purine derivatives|
|Abstract:||The present invention provides for the compound and synthesis of 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine, which compound is an intermediate involved in the synthesis of penciclovir and famciclovir.|
|Inventor(s):|| Geen; Graham Richard (Dunmow, GB), Jarvest; Richard Lewis (Ware, GB) |
|Assignee:|| SmithKline Beecham plc (Brentford, GB) |
|Filing Date:||Jan 27, 1999|
|Claims:||1. A process for the preparation of 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine which process comprises the reaction of 2-amino-6-chloropurine with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate. |
2. The process according to claim 1 wherein the leaving group is halo.
3. The process according to claim 2 wherein the leaving group is bromo.
4. The process according to claim 2 wherein the leaving group is iodo.