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Generated: August 20, 2017

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Title: Process for the preparation of purine derivatives
Abstract:The present invention provides for the compound and synthesis of 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine, which compound is an intermediate involved in the synthesis of penciclovir and famciclovir.
Inventor(s): Geen; Graham Richard (Dunmow, GB), Jarvest; Richard Lewis (Ware, GB)
Assignee: SmithKline Beecham plc (Brentford, GB)
Filing Date:Jan 27, 1999
Application Number:09/238,777
Claims:1. A process for the preparation of 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine which process comprises the reaction of 2-amino-6-chloropurine with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate.

2. The process according to claim 1 wherein the leaving group is halo.

3. The process according to claim 2 wherein the leaving group is bromo.

4. The process according to claim 2 wherein the leaving group is iodo.
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US Department of Justice
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Fuji

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