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Last Updated: April 26, 2024

Details for Patent: 6,187,922

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Title:	Process for the preparation of purine derivatives
Abstract:	The present invention provides for the compound and synthesis of 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine, which compound is an intermediate involved in the synthesis of penciclovir and famciclovir.
Inventor(s):	Geen; Graham Richard (Dunmow, GB), Jarvest; Richard Lewis (Ware, GB)
Assignee:	SmithKline Beecham plc (Brentford, GB)
Filing Date:	Jan 27, 1999
Application Number:	09/238,777
Claims:	1. A process for the preparation of 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine which process comprises the reaction of 2-amino-6-chloropurine with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate. 2. The process according to claim 1 wherein the leaving group is halo. 3. The process according to claim 2 wherein the leaving group is bromo. 4. The process according to claim 2 wherein the leaving group is iodo.

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