|Title:||High affinity nucleic acid ligands of complement system proteins|
|Abstract:||Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention arc specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.|
|Inventor(s):||Biesecker; Gregory (Boulder, CO), Gold; Larry (Boulder, CO)|
|Assignee:||NeXstar Pharmaceuticals, Inc. (Boulder, CO)|
|Filing Date:||Feb 12, 1998|
|Claims:||1. A purified and non-naturally occurring RNA Ligand to C1q, wherein said ligand is selected from the group consisting of SEQ ID NOS:84-155. |
2. A purified and non-naturally occurring RNA Ligand to C3, wherein said ligand is selected from the group consisting of SEQ ID NOS:21-46.
3. A purified and non naturally occurring RNA Ligand to C5, wherein said ligand is selected from the group consisting of SEQ ID NOS:47-83.
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