Details for Patent: 6,140,312

Title:	Formulations containing hyaluronic acid
Abstract:	The invention relates to a method of rapidly transporting a drug to the epidermis and accumulating and maintaining the drug therein for a prolonged period of time comprising administration of a therapeutically efective non-toxic amount of the drug with an effective amount of hyaluronic acid.
Inventor(s):	Falk; Rudolf Edger (Toronto, CA), Asculai; Samuel Simon (Toronto, CA), Hochman; David (Thornhill, CA), Purschke; Don (Toronto, CA), Klein; Ehud Shmuel (Givat Savyon, IL), Harper; David William (Oakville, CA)
Assignee:	Hyal Pharmaceutical Corporation (Mississauga, CA)
Filing Date:	Jun 06, 1995
Application Number:	08/466,714
Claims:	1. Pharmaceutical compositions from which effective non-toxic dosage amounts may be taken and applied to the skin or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical application, an effective non-toxic dosage amount of a drug to treat a disease or condition of the skin or exposed tissue of a human involving a pathology, and an effective non-toxic dosage amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and its non-toxic salts and combinations thereof sufficient to transport the drug into the epidermis or exposed tissue of the disease or condition involving a pathology to be treated wherein the dosage amount of the composition accumulates and remains in the epidermis for a prolonged period of time and which is systemic independent acting and wherein the form of hyaluronic acid present is between about 1% and about 3% by weight of the dosage amount and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons and greater than 150,000 daltons. 2. A method of rapidly transporting a drug to the epidermis and accumulating and maintaining the drug therein for a prolonged period of time, the method comprising topically administering a composition comprising together with pharmaceutical excipients suitable for topical application, a therapeutically effective non-toxic dosage amount of a drug to treat a disease or condition of the skin or exposed tissue involving a pathology, and an amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and its non-toxic salts and combinations thereof sufficient to facilitate the rapid transport of the drug to the site in the skin or tissue of the disease or condition to the site of the pathology or trauma to accumulate there and be retained there for a prolonged period of time and wherein the form of hyaluronic acid is administered in excess of 5 mg. per cm.sup.2, and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons and greater than 150,000 daltons. 3. The method of claim 2 wherein the form of hyaluronic acid is sodium hyaluronate. 4. The composition of claim 1 wherein the drug present is between about 1% and about 5% by weight of the dosage amount and the form of hyaluronic acid is sodium hyaluronate. 5. The method of claim 2 wherein the form of hyaluronic acid present is between about 1% and about 3% by weight of the dosage amount. 6. The method of claim 2 wherein the drug present is between about 1% and about 5% by weight of the dosage amount.