.

Deeper Knowledge, Faster

  • Find suppliers and generic API sources
  • Uncover prior art in expired and abandoned patents
  • Set up watchlists for daily email updates

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

McKesson
Medtronic
Fuji
US Army
Cantor Fitzgerald
UBS
Chinese Patent Office
US Department of Justice
Express Scripts
Teva

Generated: June 24, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,060,506

« Back to Dashboard

Details for Patent: 6,060,506

Title: Benzopyran derivatives as melatonergic agents
Abstract:Novel derivatives of benzopyran are provided which are useful as melatonergic agents.
Inventor(s): Catt; John D. (Southington, CT), Johnson; Graham (Madison, CT), Keavy; Daniel J. (Killingworth, CT), Mattson; Ronald J. (Meriden, CT), Parker; Michael F. (Middletown, CT), Takaki; Katherine S. (Middletown, CT), Yevich; Joseph P. (Southington, CT)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Filing Date:Jul 13, 1999
Application Number:09/352,560
Claims:1. A compound of Formula I or a pharmaceutically acceptable solvate thereof having the Formula: ##STR28## wherein Q.sup.1 and Q.sup.2 each are independently hydrogen or halogen;

X is CH.sub.2 ;

Y is (CH.sub.2).sub.n, with n=2-3;

Z is oxygen;

R is hydrogen, halogen or C.sub.1-4 alkyl in both cases;

m is 1 or 2;

R.sup.1 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-3 haloalkyl, C.sub.1-6 alkylamino, C.sub.2-6 alkenyl, C.sub.1-4 alkoxy(C.sub.1-4)alkyl, C.sub.1-4 alkylthio(C.sub.1-4)alkyl or C.sub.1-4 trifluoromethylalkyl; and

R.sup.2 is hydrogen or C.sub.1-4 alkyl.

2. The compound of claim 1 wherein Q.sup.1 and Q.sup.2 are independently hydrogen or iodo and m is 1.

3. The compound of claim 2 wherein R.sup.1 is C.sub.1-6 alkyl, C.sub.3-4 cycloalkyl, C.sub.1-3 haloalkyl, C.sub.2-3 alkenyl, C.sub.1-2 alkoxy(C.sub.1-2)alkyl or C.sub.1-2 trifluoromethylalkyl and R.sup.2 is hydrogen.

4. A compound of claim 3 selected from the group consisting of:

(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]propa namide;

(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]cyclo propane carboxamide;

(-)-(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]p ropanamide;

(-)-(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]a cetamide;

(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]butan amide;

(+)-(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]p ropanamide; and

(-)-(trans)-N-[[2-(3,4-dihydro-2H-1-benzopyran-5-yl)cycloprop-1-yl]methyl]c yclopropane carboxamide.

5. A method of treating sleep disorders in a patient in need of such treatment comprising administering to said patient a therapeutic amount of a compound of claim 1.

6. A composition useful for treating sleep disorders comprising a therapeutic amount of a compound of claim 1 and a suitable amount of a pharmaceutically acceptable carrier.

7. A method of treating circadian rhythm-related disorders in a patient in need of such treatment comprising administering to said patient a therapeutic amount of a compound of claim 1.

8. A composition useful for treating circadian rhythm-related disorders comprising a therapeutic amount of a compound of claim 1 and a suitable amount of a pharmaceutically acceptable carrier.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Citi
Daiichi Sankyo
Medtronic
Boehringer Ingelheim
Baxter
Fish and Richardson
Moodys
McKesson
Dow
Argus Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot