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Details for Patent: 6,001,884

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Details for Patent: 6,001,884

Title: Calcium receptor-active molecules
Abstract:The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca.sup.2+ on a calcium receptor. The preferred use of such molecules is to treat diseases or disorders by altering inorganic ion receptor activity, preferably calcium receptor activity.
Inventor(s): Nemeth; Edward F. (Salt Lake City, UT), Van Wagenen; Bradford C. (Salt Lake City, UT), Balandrin; Manuel F. (Sandy, UT), Delmar; Eric G. (Salt Lake City, UT), Moe; Scott T. (Salt Lake City, UT)
Assignee: NPS Pharmaceuticals, Inc. (Salt Lake City, UT)
Filing Date:Jun 06, 1995
Application Number:08/469,204
Claims:1. A compound having the formula: ##STR3## wherein each X and Y independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X or two Y, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F, CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, a fused aliphatic ring made up of two X or two Y, an attached aromatic ring, and a fused aromatic ring made up of two X or two Y;

R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, butyl, allyl, isobutyl, t-butyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, indenyl, indanyl, dihydroindolyl, thiodihydroindolyl, and 2-, 3-, or 4-piperid(in)yl; and

each m and n is independently between 0 and 5 inclusive; provided that two of X together make up a fused phenyl to form a naphthyl which may be substituted;

provided that if R is hydrogen, then Y.sub.n is not 2-hydroxy-3-CH.sub.3 O, 2-hydroxy-3-CH.sub.3 CH.sub.2 O, or 4-hydroxy;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein each X and Y independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X or two Y, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F, CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X or two Y; provided that if n is 1 then Y is a substituent other than hydroxy, alkyl or halogen.

3. The compound of claim 2 wherein R is selected from the group consisting of H, CH.sub.3, ethyl, and isopropyl.

4. The compound of claim 3 wherein each Y is independently selected from the group consisting of isopropyl, CH.sub.3 O, CH.sub.3 S, CF.sub.3 O, an aliphatic ring, an attached aromatic ring and a fused aromatic ring made up of two Y.

5. The compound of claim 4, wherein n is 1-5.

6. The compound of claim 5, wherein R is either H or CH.sub.3, and n is 2-5.

7. A compound having the chemical formula of either, ##STR4## or a pharmaceutically acceptable salt thereof.

8. The compound of claim 7, wherein said compound is selected from the group consisting of ##STR5## or a pharmaceutically acceptable salt thereof.

9. The compound of claim 7, wherein said compound is ##STR6## or a pharmaceutically acceptable salt thereof.

10. The compound of claim 7, wherein said compound is ##STR7## or a pharmaceutically acceptable salt thereof.

11. The compound of claim 7, wherein said compound is ##STR8## or a pharmaceutically acceptable salt thereof.

12. The compound of claim 7, wherein said compound is ##STR9## or a pharmaceutically acceptable salt thereof.

13. The compound of claim 7, wherein said compound is ##STR10## or a pharmaceutically acceptable salt thereof.

14. The compound of claim 7, wherein said compound is ##STR11## or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula: ##STR12## wherein each X independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F, CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, a fused aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X together; provided that a fused phenyl made up of two of X together is present to form an optionally substituted naphthyl;

R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, butyl, allyl, isobutyl, t-butyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, indenyl, indanyl, dihydroindolyl, thiodihydroindolyl, and 2-, 3-, or 4-piperid(in)yl; and

each m is independently between 0 and 5 inclusive; or a pharmaceutically acceptable salt thereof.

16. The composition of claim 15 wherein each X independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X; and R is selected from the group consisting of H, CH.sub.3, ethyl, and isopropyl.

17. The composition of claim 16, wherein each X is independently selected from the group consisting of isopropyl, CH.sub.3 O, CH.sub.3 S, CF.sub.3 O, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X together; and each m is 2-5.

18. The composition of claim 17, wherein R is either H or CH.sub.3.

19. The composition of claim 15, wherein said compound is either ##STR13## or a pharmaceutically acceptable salt thereof.

20. The composition of claim 15, wherein said compound is ##STR14## or a pharmaceutically acceptable salt thereof.

21. The composition of claim 15, wherein said compound is ##STR15## or a pharmaceutically acceptable salt thereof.

22. The composition of claim 15, wherein said compound is ##STR16## or a pharmaceutically acceptable salt thereof.

23. The composition of claim 15, wherein said compound is ##STR17## or a pharmaceutically acceptable salt thereof.

24. The composition of claim 15, wherein said compound is ##STR18## or a pharmaceutically acceptable salt thereof.

25. A method for treating a patient having a disease or disorder characterized by abnormal calcium homeostasis comprising the step of administering to said patient a therapeutically effective amount of a compound having the formula: ##STR19## wherein each X independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F, CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X together; provided that a fused phenyl made up of two of X together is present to form an optionally substituted naphthyl;

R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, butyl, allyl, isobutyl, t-butyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, indenyl, indanyl, dihydroindolyl, thiodihydroindolyl, and 2-, 3-, or 4-piperid(in)yl; and

each m is independently between 0 and 5 inclusive; or a pharmaceutically acceptable salt thereof.

26. The method of claim 25, wherein each X independently is selected from the group consisting of CH.sub.3, CH.sub.3 O, CH.sub.3 CH.sub.2 O, methylene dioxy made up of two X, Br, Cl, F, CF.sub.3, CHF.sub.2, CH.sub.2 F, CF.sub.3 O, CH.sub.3 S, OH, CH.sub.2 OH, CONH.sub.2, CN, NO.sub.2, CH.sub.3 CH.sub.2, propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X; R is selected from the group consisting of H, CH.sub.3, ethyl, and isopropyl.

27. The method of claim 26, wherein each X is independently selected from the group consisting of isopropyl, CH.sub.3 O, CH.sub.3 S, CF.sub.3 O, an aliphatic ring, an attached aromatic ring, and a fused aromatic ring made up of two X together.

28. The method of claim 27, wherein R is either H or CH.sub.3, and each m is 2-5.

29. The method of claim 25, wherein said compound is either ##STR20## or a pharmaceutically acceptable salt thereof.

30. The method of claim 25, wherein said compound is ##STR21## or a pharmaceutically acceptable salt thereof.

31. The method of claim 25, wherein said compound is ##STR22## or a pharmaceutically acceptable salt thereof.

32. The method of claim 25, wherein said compound is ##STR23## or a pharmaceutically acceptable salt thereof.

33. The method of claim 25, wherein said compound is ##STR24## or a pharmaceutically acceptable salt thereof.

34. The method of claim 25, wherein said compound is ##STR25## or a pharmaceutically acceptable salt thereof.

35. The method of any of one of claims 25-34, wherein said method is used to treat primary or secondary hyperparathyroidism.

36. The method of any of one of claims 25-34, wherein said method is used to treat Paget's disease.

37. The method of any of one of claims 25-34, wherein said method is used to decrease parathyroid hormone level in said patient to achieve a beneficial effect.

38. The method of any of one of claims 25-34, wherein said method is used to treat hypertension.

39. The method of any of one of claims 25-34, wherein said method is used to treat osteoporosis.

40. A method of treating a patient having a disease or disorder characterized by abnormal calcium homeostasis comprising the step of administering to said patient an effective amount of the compound of claim 15.

41. A method according to claim 40 wherein said disease or disorder is selected from the group consisting of hyperparathyroidism, osteoporosis, gut motility disorders, diarrhea, GI ulcer diseases, GI absorption diseases, sarcoidosis, and autoimmune diseases.

42. A method according to claim 40 wherein said disease or disorder is selected from the group consisting of seizures, stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage caused by cardiac arrest or neonatal distress, hypertension, and epilepsy.

43. A method according to claim 40 wherein said disease or disorder is selected from the group consisting of syndrome of inappropriate ADH secretion, cirrhosis, nephrosis, and heart failure.

44. A method according to claim 40 wherein said disease or disorder is selected from the group consisting of Alzheimer's disease, Huntington's disease, Parkinson's disease, dementia, muscle tension, depression, anxiety, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, neuroleptic malignant syndrome, and Tourette's syndrome.
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