Details for Patent: 6,001,876
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Title: | Isobutylgaba and its derivatives for the treatment of pain |
Abstract: | The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy. |
Inventor(s): | Singh; Lakhbir (Cambridgeshire, GB) |
Assignee: | Warner-Lambert Company (Morris Plains, NJ) |
Filing Date: | Jul 15, 1998 |
Application Number: | 09/043,358 |
Claims: | 1. A method for treating pain comprising administering a therapeutically effective amount of a compound of Formula I ##STR2## or a pharmaceutically acceptable salt, diastereomer, or enantiomer thereof wherein R.sub.1 is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl, or carboxyl to a mammal in need of said treatment. 2. A method according to claim 1 wherein the compound administered is a compound of Formula I wherein R.sub.3 and R.sub.2 are hydrogen, and R.sub.1 is --(CH.sub.2).sub.0-2 --i C.sub.4 H.sub.9 as an (R), (S), or (R,S) isomer. 3. A method according to claim 1 wherein the compound administered is named (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methyl-hexanoic acid. 4. A method according to claim 1 wherein the pain treated is inflammatory pain. 5. A method according to claim 1 wherein the pain treated is neuropathic pain. 6. A method according to claim 1 wherein the pain treated is cancer pain. 7. A method according to claim 1 wherein the pain treated is postoperative pain. 8. A method according to claim 1 wherein the pain treated is phantom limit pain. 9. A method according to claim 1 wherein the pain treated is bum pain. 10. A method according to claim 1 wherein the pain treated is gout pain. 11. A method according to claim 1 wherein the pain treated is osteoarthritic pain. 12. A method according to claim 1 wherein the pain treated is trigeminal neuralgia pain. 13. A method according to claim 1 wherein the pain treated is acute herpetic and postherpetic pain. 14. A method according to claim 1 wherein the pain treated is causalgia pain. 15. A method according to claim 1 wherein the pain treated is idiopathic pain. |