|Abstract:||The present invention relates to methods for preparing and using compounds of formula (I), wherein carbons 1 and 2 are joined by either a single or a double bond; R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or methyl; R.sup.3 is (A) wherein X, W, Z, R.sup.4, and R.sup.5, are various groups, and pharmaceutically acceptable solvates thereof and their use in the treatment of androgen responsive and mediated diseases.|
|Inventor(s):|| Batchelor; Kenneth William (Durham, NC), Frye; Stephen Vernon (Durham, NC) |
|Assignee:|| Glaxo Wellcome Inc. (Research Triangle Park, NC) |
|Filing Date:||May 14, 1998|
|Claims:||1. A method of treating an androgen responsive or mediated disease or condition in a mammal suffering from said disease comprising administering to said mammal, an effective amount of a compound of formula (1) ##STR16## wherein carbons 1 and 2 are joined by either a single or a double bond; R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or methyl; R.sup.3 is ##STR17## wherein R.sup.4 and R.sup.5 are independently hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, cyano, halogen, phenyl (optionally substituted with one or more halogens), or when R.sup.4 and R.sup.5 are on adjacent carbons, taken together form a fused 5, 6 or 7 member ring optionally containing one or more oxygen or sulfur atoms; W and Z are alkylene groups which taken together with the carbon to which they are attached form a saturated, 3 to 12 member ring system optionally substituted independently with one or more lower alkyl groups or two of said alkyl groups of said 3 to 12 member ring can joined with a (C.sub.1-6) alkylene group to form a bicyclic ring system, and wherein said 3 to 12 member ring can optionally have an oxygen or sulfur atom,; and X is hydrogen or halogen. |
2. A method of claim 1 wherein the androgen responsive or mediated disease or condition is benign prostatic hyperplasia, prostate cancer, acne, male pattern baldness, or hirsuitism.