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Title: High affinity PDGF nucleic acid ligands
Abstract:Methods are described for the identification and preparation of high-affinity nucleic acid ligands to PDGF. Included in the invention are specific ssDNA and RNA ligands to PDGF identified by the SELEX method.
Inventor(s): Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Filing Date:Mar 20, 1996
Application Number:08/618,693
Claims:1. A purified and isolated non-naturally occurring DNA ligand to Platelet Derived Growth Factor (PDGF) wherein said ligand is selected from the group consisting of SEQ ID NOS:82-87.

2. A purified and isolated non-naturally occurring nucleic acid ligand to PDGF comprising the conserved structure shown in FIG. 1.

3. The purified and isolated non-naturally occurring DNA ligand to PDGF of claim 1 consisting of the nucleotide sequence of SEQ ID NO:87.
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Healthtrust
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