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Generated: August 17, 2017

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Title: Calcium receptor-active molecules
Abstract:The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
Inventor(s): Brown; Edward M. (Milton, MA), Fuller; Forrest H. (Salt Lake City, UT), Hebert; Steven C. (Wellesley, MA), Garrett, Jr.; James E. (Salt Lake City, UT)
Assignee: The Brigham & Women's Hospital, Inc. (Boston, MA) NPS Pharmaceuticals, Inc. (Salt Lake City, UT)
Filing Date:Jun 07, 1995
Application Number:08/485,588
Claims:1. A purified nucleic acid comprising at least 20 contiguous nucleotides of a nucleic acid sequence provided in SEQ ID NO: 1.

2. The purified nucleic acid of claim 1 comprising 27 contiguous nucleotides of said nucleic acid sequence.

3. The purified nucleic acid of claim 1 comprising at least 45 contiguous nucleotides of said nucleic acid sequence.

4. A purified nucleic acid comprising a nucleic acid sequence encoding at least 12 contiguous amino acids of an amino acid sequence provided in SEQ ID NO: 5.

5. The purified nucleic acid of claim 4, wherein said nucleic acid encodes at least 18 contiguous amino acids of said amino acid sequence.

6. The purified nucleic acid of claim 5 wherein said nucleic acid encodes at least 54 contiguous amino acids of said amino acid sequence.

7. The purified nucleic acid of claim 4 wherein said nucleic acid encodes an extracellular binding domain, but is substantially free of transmembrane and intracellular domain portions.

8. The purified nucleic acid of claim 4 wherein the nucleic acid encodes an intracellular domain but is free of transmembrane and extracellular domains.

9. The purified nucleic acid of claim 4 wherein the nucleic acid encodes a transmembrane domain but is free of intracelluar and extracellular domains.

10. The purified nucleic acid of claim 4 wherein the nucleic acid encodes an extracellular binding domain, and said nucleic acid encoding an extracellular binding domain is transcriptionally coupled to a second nucleic acid encoding transmembrane and intracellular coding domains of a non-inorganic ion receptor.

11. A purified nucleic acid comprising a nucleotide sequence which comprises at least 16 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.

12. A purified nucleic acid comprising a nucleotide sequence which comprises at least 18 nucleotides hybridizing under stringent conditions to at least 20 continuous nucleotides provided in SEQ ID NO:1.

13. A purified nucleic acid comprising a nucleotide sequence which comprises at least 19 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.

14. A purified nucleic acid comprising a nucleotide sequence which comprises at least 20 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.

15. A purified nucleic acid comprising a nucleic acid sequence selected from the consisting of: SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8.

16. The nucleic acid of claim 15, wherein said nucleic acid sequence is SEQ ID NO: 5.

17. The nucleic acid of claim 15, wherein said nucleic acid sequence is SEQ ID NO: 6.

18. The nucleic acid of claim 15, wherein said nucleic acid sequence is SEQ ID NO: 7.

19. The nucleic acid of claim 15, wherein said nucleic acid sequence is SEQ ID NO: 8.

20. A purified nucleic acid comprising a nucleic acid sequence encoding an amine acid sequence selected from the group consisting of SEQ ID NO: 5. SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO: 8.

21. The nucleic acid of claim 20, wherein said amine acid sequence is SEQ ID NO: 5.

22. The nucleic acid of claim 20, wherein said amine acid sequence is SEQ ID NO: 6.

23. The nucleic acid of claim 20, wherein said amine acid sequence is SEQ ID NO: 7.

24. The nucleic acid of claim 20, wherein said amino acid sequence is SEQ ID NO: 8.
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