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Details for Patent: 5,637,461

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Details for Patent: 5,637,461

Title: Ligands of HIV-1 TAT protein
Abstract:Methods are described for the identification of nucleic acid ligand solutions to the HIV-1 tat protein. Motifs I, II and III are nucleic acid ligands identified by the disclosed methods.
Inventor(s): Gold; Larry M. (Boulder, CO), Tuerk; Craig (Boulder, CO)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Filing Date:Mar 24, 1995
Application Number:08/409,439
Claims:1. A method for identifying non-naturally occurring single-stranded nucleic acid ligands to the HIV-1 tat protein comprising:

a) preparing a candidate mixture comprising non-naturally occurring single-stranded nucleic acids;

b) contacting said candidate mixture with the HIV-1 tat protein, wherein non-naturally occurring single-stranded nucleic acids having an increased affinity to the HIV-1 tat protein relative to the candidate mixture may be partitioned from the remainder of the candidate mixture;

c) partitioning said increased affinity non-naturally occurring single-stranded nucleic acids from the remainder of the candidate mixture; and

d) amplifying said increased affinity non-naturally occurring single-stranded nucleic acids to yield a mixture of non-naturally occurring single-stranded nucleic acids enriched in non-naturally occurring single-stranded nucleic acids having increased affinity to the HIV-1 tat protein, whereby non-naturally occurring single-stranded nucleic acid ligands to the HIV-1 tat protein are identified.

2. The method of claim 1 further comprising e) repeating steps b), c)and d).

3. The method of claim 1 wherein said candidate mixture of non-naturally occurring single-stranded nucleic acids contacted with the HIV-1 tat protein is comprised of RNA.
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