Details for Patent: 5,246,708

Title:	Methods for promoting wound healing with deoxyribonucleosides
Abstract:	Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine, 2'-deoxy-cytidine, or thymidine. 3'- and 5'-phosphate derivatives of these 2'-deoxynucleosides are also effective in promoting wound healing.
Inventor(s):	von Borstel; Reid W. (Kensington, MD), Bamat; Michael K. (Chevy Chase, MD)
Assignee:	Pro-Neuron, Inc. (Rockville, MD)
Filing Date:	Jul 13, 1992
Application Number:	07/911,379
Claims:	1. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 2. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 3. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 4. A method as in claim 1 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 5. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'- or 5'-phosphate, or a 3'- or 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 6. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 7. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 8. A method as in claim 6 wherein said composition of matter further comprises (d) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 9. A method as in claim 1 or 5 further comprising a pharmaceutically acceptable carrier. 10. A method as in claim 1 or 5 wherein said wound is a mucosal wound. 11. A method as in claim 1 or 5 wherein said wound is a dermal wound. 12. A method as in claim 1 or 5 wherein said wound is a surgical incision. 13. A method as in claim 1 or 5 wherein said wound is a burn. 14. A method as in claim 1 or 5 wherein said wound is an ulcer. 15. A method as in claim 14 wherein said ulcer is a dermal ulcer. 16. A method as in claim 14 wherein said ulcer is a mucosal ulcer. 17. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 18. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 19. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 20. A method as in claim 18 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 21. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3', a 5' phosphate, or a 3',5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 22. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 23. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 24. A method as in claim 22 wherein said composition of matter further comprises (d) a, 3',5' phosphate or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 25. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome. 26. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 27. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 28. A method as in claim 26 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 29. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome. 30. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 31. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 32. A method as in claim 30 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 33. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 34. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 35. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 36. A method as in claim 34 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 37. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof. 38. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 39. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 40. A method as in claim 38 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.