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Details for Patent: 5,246,708

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Details for Patent: 5,246,708

Title: Methods for promoting wound healing with deoxyribonucleosides
Abstract:Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine, 2'-deoxy-cytidine, or thymidine. 3'- and 5'-phosphate derivatives of these 2'-deoxynucleosides are also effective in promoting wound healing.
Inventor(s): von Borstel; Reid W. (Kensington, MD), Bamat; Michael K. (Chevy Chase, MD)
Assignee: Pro-Neuron, Inc. (Rockville, MD)
Filing Date:Jul 13, 1992
Application Number:07/911,379
Claims:1. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof.

2. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.

3. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

4. A method as in claim 1 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

5. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol of a 3'- or 5'-phosphate, or a 3'- or 5'-diphosphate ester of 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof.

6. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.

7. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

8. A method as in claim 6 wherein said composition of matter further comprises (d) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

9. A method as in claim 1 or 5 further comprising a pharmaceutically acceptable carrier.

10. A method as in claim 1 or 5 wherein said wound is a mucosal wound.

11. A method as in claim 1 or 5 wherein said wound is a dermal wound.

12. A method as in claim 1 or 5 wherein said wound is a surgical incision.

13. A method as in claim 1 or 5 wherein said wound is a burn.

14. A method as in claim 1 or 5 wherein said wound is an ulcer.

15. A method as in claim 14 wherein said ulcer is a dermal ulcer.

16. A method as in claim 14 wherein said ulcer is a mucosal ulcer.

17. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof.

18. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.

19. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

20. A method as in claim 18 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

21. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol of a 3', a 5' phosphate, or a 3',5'-diphosphate ester of 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof.

22. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.

23. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

24. A method as in claim 22 wherein said composition of matter further comprises (d) a, 3',5' phosphate or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

25. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof, in the form of a liposome.

26. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.

27. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

28. A method as in claim 26 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

29. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof, in the form of a liposome.

30. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.

31. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

32. A method as in claim 30 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

33. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.

34. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.

35. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

36. A method as in claim 34 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.

37. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising,

(a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and

(b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine,

or the pharmaceutically acceptable salts thereof.

38. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.

39. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.

40. A method as in claim 38 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
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