You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 26, 2024

Claims for Patent: 9,987,263

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 9,987,263

Title:	Methods for treatment of Fabry disease
Abstract:	Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
Inventor(s):	Lockhart; David J. (Del Mar, CA), Castelli; Jeff (New Hope, PA)
Assignee:	Amicus Therapeutics, Inc. (Cranbury, NJ)
Application Number:	15/338,923
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,987,263
Patent Claims:	1. A method for treatment of Fabry disease in a human patient in need thereof, the method comprising administering to the patient an oral dosage form comprising 150 mg of 1-deoxygalactonojirimycin or a salt thereof every other day. 2. The method of claim 1, wherein the oral dosage form comprises a tablet, a capsule or a solution. 3. The method of claim 1, wherein the oral dosage form comprises a capsule. 4. The method of claim 1, wherein the 1-deoxygalactonojirimycin or a salt thereof enhances .alpha.-galactosidase A activity. 5. The method of claim 1, wherein the patient has an .alpha.-galactosidase A mutation selected from the group consisting of T41I, A143T, A97V, M51K, L300P, G328A, P205T and N215S. 6. The method of claim 1, wherein the patient is male. 7. The method of claim 1, wherein the patient is female. 8. A method for treatment of Fabry disease in a human patient in need thereof, the method comprising administering to the patient an oral dosage form comprising 150 mg of migalastat hydrochloride every other day. 9. The method of claim 8, wherein the oral dosage form comprises a tablet, a capsule or a solution. 10. The method of claim 8, wherein the oral dosage form comprises a capsule. 11. The method of claim 8, wherein the migalastat hydrochloride enhances .alpha.-galactosidase A activity. 12. The method of claim 8, wherein the patient has an .alpha.-galactosidase A mutation selected from the group consisting of T41I, A143T, A97V, M51K, L300P, G328A, P205T and N215S. 13. The method of claim 8, wherein the patient is male. 14. The method of claim 8, wherein the patient is female. 15. The method of claim 1, wherein the patient has an .alpha.-galactosidase A mutation selected from the group consisting of A156V, D244N, E59K, F113L, G144V, G183D, G328A, I91T, L166V, L32P, M284T, M296I, M296V, N263S, Q279E, R363C, R363H, N34S, T41I, M51K, A97V, R112H, A143T, P205T, Y207S, N215S, P259R, N263S, L300P, R301Q, E358A, P409A, S201F, P205T and F295C. 16. The method of claim 8, wherein the patient has an .alpha.-galactosidase A mutation selected from the group consisting of A156V, D244N, E59K, F113L, G144V, G183D, G328A, I91T, L166V, L32P, M284T, M296I, M296V, N263S, Q279E, R363C, R363H, N34S, T41I, M51K, A97V, R112H, A143T, P205T, Y207S, N215S, P259R, N263S, L300P, R301Q, E358A, P409A, S201F, P205T and F295C.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.